Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.
Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.
复制标题
适度及后续渐进性体重减轻对肥胖人群代谢功能和脂肪组织生物学的影响。
DOI：
10.1016/j.cmet.2016.02.005
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发表时间：
2016-04-12
期刊：
影响因子：
29
通讯作者：
Klein S
中科院分区：
文献类型：
--
作者：
Magkos F;Fraterrigo G;Yoshino J;Luecking C;Kirbach K;Kelly SC;de Las Fuentes L;He S;Okunade AL;Patterson BW;Klein S
虽然5%-10%的体重减轻是肥胖症患者的常规建议，但5%和进一步减肥对代谢健康的确切影响尚不清楚。我们进行了一项随机对照试验，评估了5.1±0.9%（n=19），10.8±1.3%（n=9）和16.4±2.1%（n=9）体重减轻和体重维持（n=14）对代谢结果的影响。5%的体重减轻改善了脂肪组织、肝脏和肌肉胰岛素敏感性以及β细胞功能，而全身或皮下脂肪组织炎症标志物没有伴随变化。额外的体重减轻进一步改善了肌肉中的β细胞功能和胰岛素敏感性，并导致脂肪组织质量、肝内甘油三酯含量以及参与胆固醇通量、脂质合成、细胞外基质重塑和氧化应激的基因的脂肪组织表达的逐步变化。这些结果表明，适度的5%体重减轻同时改善了多个器官的代谢功能，并且渐进性体重减轻导致关键脂肪组织生物学途径的剂量依赖性改变。Magkos等人证明了减肥对肥胖受试者代谢功能的深远治疗作用。即使是适度的5%体重减轻也有相当大的健康益处，包括减少腹腔内和肝内脂肪，增加多器官胰岛素敏感性和β细胞功能。额外的体重减轻进一步改善了许多心脏代谢结果。
Although 5%–10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1±0.9% (n=19), 10.8±1.3% (n=9) and 16.4±2.1% (n=9) weight loss, and weight maintenance (n=14) on metabolic outcomes. Five percent weight loss improved adipose tissue, liver and muscle insulin sensitivity, and β-cell function, without a concomitant change in systemic or subcutaneous adipose tissue markers of inflammation. Additional weight loss further improved β-cell function and insulin sensitivity in muscle, and caused stepwise changes in adipose tissue mass, intrahepatic triglyceride content, and adipose tissue expression of genes involved in cholesterol flux, lipid synthesis, extracellular matrix remodeling and oxidative stress. These results demonstrate that moderate 5% weight loss improves metabolic function in multiple organs simultaneously, and progressive weight loss causes dose-dependent alterations in key adipose tissue biological pathways. Magkos et al. demonstrate the profound therapeutic effects of weight loss on metabolic function in subjects with obesity. Even a moderate 5% weight loss has considerable health benefits, including decreased intra-abdominal and intra-hepatic fat, and increased multi-organ insulin sensitivity and β-cell function. Additional weight loss further improves many cardiometabolic outcomes.