Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19
Identification of a novel cerebral malaria susceptibility locus (Berr5) on mouse chromosome 19
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DOI：
10.1038/gene.2009.79
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发表时间：
2010-06-01
影响因子：
5
通讯作者：
Gros, P.
中科院分区：
文献类型：
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作者：
Berghout, J.;Min-Oo, G.;Gros, P.
脑型疟疾(CM)是一种以高烧、癫痫发作和昏迷为特征的急性、一般致命的疾病。CM的遗传成分可以在对伯氏疟原虫感染程度不同的小鼠模型中进行研究。用存活时间来测量一个信息丰富的F2杂交组合(n=257)的敏感性，我们发现了与19号染色体(Berr5(berghei抗性基因5)，LOD=4.69)的连锁，部分控制了抗性BALB/c和敏感C57BL/6祖代之间的差异反应。Balb/c等位基因通过感染的大脑阶段传递增加的存活率，但在较晚的贫血阶段对寄生虫血症没有定量影响。Berr5基因与其他三个免疫基因座共定位，包括Trl-4(结核病耐药)、Tsiq2(T细胞分泌IL-4)和Eae19(实验性变态反应性脑炎19)，这表明这些表型可能存在共同的遗传效应。潜在的候选位置包括IFIT1-3(带有四肽重复序列1-3的干扰素诱导蛋白)和Fas家族。基因与免疫(2010年)11,310-318；DOI：10.1038/gene.2009.79；在线发布
Cerebral malaria (CM) is an acute, generally lethal condition characterized by high fever, seizures and coma. The genetic component to CM can be investigated in mouse models that vary in degree of susceptibility to infection with Plasmodium berghei ANKA. Using survival time to measure susceptibility in an informative F2 cross (n=257), we identified linkage to chromosome 19 (Berr5 (Berghei resistance locus 5), LOD=4.69) controlling, in part, the differential response between resistant BALB/c and susceptible C57BL/6 progenitors. BALB/c alleles convey increased survival through the cerebral phase of infection but have no quantitative effect on parasitemia during the later, anemic phase. The Berr5 locus colocalizes with three other immune loci, including Trl-4 (tuberculosis resistance), Tsiq2 (T-cell secretion of IL-4) and Eae19 (experimental allergic encephalitis 19), suggesting the possibility of a common genetic effect underlying these phenotypes. Potential positional candidates include the family of Ifit1-3 (interferon-inducible protein with tetratricopeptide repeats 1-3) and Fas. Genes and Immunity (2010) 11, 310-318; doi:10.1038/gene.2009.79; published online 29 October 2009