AN ULTRASTRUCTURAL CHARACTERIZATION OF THE INTERFACE BETWEEN BONE AND SPUTTERED TITANIUM OR STAINLESS-STEEL SURFACES
AN ULTRASTRUCTURAL CHARACTERIZATION OF THE INTERFACE BETWEEN BONE AND SPUTTERED TITANIUM OR STAINLESS-STEEL SURFACES
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DOI：
10.1016/0142-9612(86)90103-1
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发表时间：
1986-05-01
期刊：
影响因子：
14
通讯作者：
HANSSON, HA
中科院分区：
文献类型：
--
作者：
ALBREKTSSON, T;HANSSON, HA
将覆有一层金属薄层的聚碳酸酯种植体植入兔的胫骨干骺端。植入物的表面要么是磁控溅射的L 316型不锈钢，要么是商业纯钛表面(或者是蒸发的商业纯钛表面)。实验的目的是研究骨与所用涂层之间的界面排列。种植体植入3个月后处死动物，用超微结构技术分析骨与金属之间的完整界面。在不锈钢的情况下，发现了一层1-2层的细胞层，将骨与金属隔开。炎性细胞丰富，蛋白多糖被膜宽，无胶原纤维。在钛的情况下，界面中没有细胞，而是由大约200-400 nm宽度的蛋白聚糖层组成。胶原束出现在距离金属表面1000-2000°的最小距离处。有时在直接接触中可见钙沉积(分辨率30-50。用二氧化钛。磁控溅射钛表面与蒸发钛表面的组织反应在超微结构上没有差异。
Experimental implants of polycarbonate covered with a thin metallic layer were inserted in the rabbit tibial metaphysics. The implants had either a magnetron sputtered 316 L stainless steel or commercially pure titanium surface (or an evaporated commerically pure titanium surface). The aim of the experiment was to investigate the interfacial arrangements between bone and the coatings used. Three months after implant insertion, the animals were sacrificed and the intact interface between bone and metal analyzed using ultrastructural techniques. In the case of stainless steel a coat of 1-2 cellular layers separating the bone from the metal was found. Inflammatory cells were abundant as well as wide proteoglycan coat lacking collagen filaments. In the case of titanium there were no cells in the interface which consisted instead of a proteoglycan layer of about 200-400 .ANG. width. Bundles of collagen appeared at a minium distance of 1000-2000 .ANG. from the metal surface. Calcium deposits were sometimes seen in direct contact (resolution level 30-50 .ANG.) with the titanium oxide. There were no ultrastructural differences in tissue reactions when magnetron sputtered titanium surfaces were compared with evaporated ones.