Presence on a human melanoma of multiple antigens recognized by autologous CTL
Presence on a human melanoma of multiple antigens recognized by autologous CTL
复制标题
人类黑色素瘤上存在多种可被自体 CTL 识别的抗原
DOI：
10.1002/ijc.2910440413
复制
发表时间：
1989
影响因子：
6.4
通讯作者：
T. Boon
中科院分区：
文献类型：
--
作者：
B. D. V. Eynde;P. Hainaut;M. Hérin;A. Knuth;C. Lemoine;P. Weynants;P. Bruggen;R. Fauchet;T. Boon
We derived from blood lymphocytes of a melanoma patient a large number of cytolytic T‐cell clones directed against a cell line of the autologous tumor. Three distinct groups of antigens were recognized by these CTL on the autologous melanoma cells: group A consisted of stable antigens present on all sublines, whereas antigens B and C appeared unstable and were expressed by distinct sublines. In vitro immunoselec‐tions with various anti‐A CTL clones were applied to the melanoma cells and variants resistant to 3 different CTL clones were obtained. These variants remained sensitive to other anti‐A CTL clones, indicating that group A comprises at least 4 different antigens (D, E, F and A). From a total of 76 CTL clones obtained from lymphocytes collected from the patient at various times, we found that 45 were anti‐B, 17 were anti‐C, 2 were anti‐D, 9 were anti‐E, 2 were anti‐F and I was anti‐A′. It is therefore likely that the 6 antigens identified by these CTL clones represent all or nearly all the transplantation antigens recognized by autologous CTL on this human melanoma.
人支气管粘液糖蛋白的复杂结构。
DOI：
10.1111/j.1432-1033.1984.tb08273.x
发表时间：
1984
期刊：
European journal of biochemistry
影响因子：
--
作者：
Slayter,HS;Lamblin,G;LeTreut,A;Galabert,C;Houdret,N;Degand,P;Roussel,P
通讯作者：
Roussel,P
DOI：
10.1073/pnas.79.14.4395
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEUER, SC;SCHLOSSMAN, SF;REINHERZ, EL
通讯作者：
REINHERZ, EL