Potential psychosocial mechanisms linking depression to immune function in elderly subjects
Potential psychosocial mechanisms linking depression to immune function in elderly subjects
复制标题
将老年抑郁与免疫功能联系起来的潜在社会心理机制
DOI：
10.1016/j.psychres.2004.05.001
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发表时间：
2004-07-15
影响因子：
11.3
通讯作者：
van den Berg, MD
中科院分区：
文献类型：
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作者：
Bouhuys, AL;Flentge, F;van den Berg, MD
尽管老年人的抑郁症和免疫变化构成了相当大的健康风险，但抑郁症和免疫功能之间联系的潜在机制尚不清楚。在21名老年抑郁症患者和23名对照者中探讨了人格和社会支持是否可以解释抑郁症患者免疫功能的变化。研究了以下变量：神经质、外向性、获得的社会支持、抑郁相关的免疫参数[即淋巴细胞数量、淋巴细胞亚群CD 3+、CD 8+、自然免疫样T细胞（NKT）、CD 4/CD 8比值和白细胞介素-6（IL-6）]。我们发现，神经质降低了抑郁症和IL-6之间的关联（从62%到22.4%），抑郁症和CD 3+之间的关联（从27.6%到21.6%），并且还与IL-6直接相关（即调整年龄和抑郁症）。社会支持将抑郁症与NKT细胞之间的关联从25%降低到18%，同时它也与NKT细胞直接相关。经年龄和抑郁校正后，外向性与CD 4/CD 8比值呈负相关。高外向性和高社会支持的受试者有更多的NKT细胞。我们的结论是，在抑郁症的免疫功能的变化可以部分解释神经质和接受社会支持，而免疫功能也直接关系到这些心理社会变量。神经质可能部分通过IL-6的产生而对抑郁症的发病起作用。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Although depression and immune changes in elderly subjects constitute a considerable health risk, mechanisms underlying the association between depression and immune function are unclear. The question of whether personality and social support can explain the variation in immune function during depression was addressed in 21 elderly depressive and 23 control subjects. The following variables were studied: neuroticism, extraversion, received social support, depression-related immune parameters [i.e. numbers of lymphocytes, lymphocyte subsets CD3+, CD8+, natural killer-like T cells (NKT), CD4/CD8 ratio, and interleukin-6 (Il-6)]. We found that neuroticism reduced the association between depression and Il-6 (from 62 to 22.4%) and between depression and CD3+ (from 27.6 to 21.6%), and was also directly related to Il-6 (i.e. adjusted for age and depression). Social support reduced the association between depression and NKT cells from 25 to 18%, while it was also directly related to NKT cells. Extraversion, adjusted for age and depression, was negatively related to CD4/CD8 ratio. Subjects with high extraversion and high social support had more NKT cells. We concluded that changes in immune function during depression can partly be explained by neuroticism and received social support, whereas immune function is also directly related to these psychosocial variables. Neuroticism may exert its contribution to the risk for depression partly via Il-6 production. (C) 2004 Elsevier Ireland Ltd. All rights reserved.