Mutation of Pseudomonas aeruginosa to piperadillin resistance mediated by β-lactamase production
Mutation of Pseudomonas aeruginosa to piperadillin resistance mediated by β-lactamase production
复制标题
β-内酰胺酶产生介导铜绿假单胞菌对哌拉西林耐药的突变
DOI：
10.1093/jac/15.6.665
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发表时间：
1985
影响因子：
5.2
通讯作者：
J. Y. Lanzarone
中科院分区：
文献类型：
--
作者：
S. Bell;J. N. Pham;J. Y. Lanzarone
结果：10株铜绿假单胞菌均检出耐药突变株。耐药性与高水平β-内酰胺酶菌株的组成性生产有关，这与亲本菌株诱导的染色体Id β-内酰胺酶的特征相似。这种类型的突变，以哌拉西林耐药发生在低频率。菌株经多次传代和长期保存后，产酶和耐哌拉西林能力稳定。
: Piperacillin-resistant mutants were detected in each of ten strains of Pseudomonas aeruginosa. The resistance was associated with constitutive production by the strains of high levels of beta-lactamase which was similar in character to the induced chromosomal Id beta-lactamase of the parent strains. This type of mutation to piperacillin-resistance occurred at a low frequency. The beta-lactamase production and piperacillin-resistance were stable on repeated subculture and prolonged storage of the strains.