Synthesis of Truncated Analogues for Studying the Process of Glycosyl Phosphatidylinositol Modification
Synthesis of Truncated Analogues for Studying the Process of Glycosyl Phosphatidylinositol Modification
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DOI：
10.1021/ol100575q
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发表时间：
2010-05-07
期刊：
影响因子：
5.2
通讯作者：
Hendrickson, Tamara L.
中科院分区：
文献类型：
--
作者：
John, Franklin;Hendrickson, Tamara L.
许多真核蛋白质在其C-末端被糖基磷脂酰肌醇(GPI)锚点修饰。这种翻译后修饰导致这些蛋白质非共价连接到质膜上。报道了截短的GPI锚定类似物的合成；这些化合物被设计为GPI转氨酶(GPI-T)的可溶性底物，GPI-T是将GPI锚定附加到蛋白质上的酶。
Many eukaryotic proteins are modified with a glycosylphosphatidylinositol (GPI) anchor at their C-termini. This post-translational modification causes these proteins to be noncovalently tethered to the plasma membrane. The synthesis of truncated GPI anchor analogues Is reported; these compounds were designed for use as soluble substrates for GPI transamidase (GPI-T), the enzyme that appends the GPI anchor onto proteins.