Multiple sclerosis and prostate cancer: what do their similar geographies suggest?
Multiple sclerosis and prostate cancer: what do their similar geographies suggest?
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多发性硬化症和前列腺癌：它们相似的地理分布表明什么？
DOI：
10.1159/000110937
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发表时间：
1992
影响因子：
5.7
通讯作者：
Schwartz,GG
中科院分区：
文献类型：
--
作者：
Schwartz,GG
多发性硬化症的死亡率显示出众所周知的南北梯度，在美国和国际上都是如此。前列腺癌的死亡率显示出类似的梯度，并且与多发性硬化症（MS）死亡率和MS患病率显着相关。这一发现将前列腺癌添加到一组疾病中，这些疾病的地理分布与MS显著相关，其成员包括结肠癌、龋齿和帕金森病。文献综述表明，这些临床上不同的疾病可能共享维生素（激素）D的畸变。最近的证据表明维生素D在免疫调节中的多方面作用表明，维生素D畸变也可能有助于MS的病因。维生素D假说可以阐明MS流行病学的几个无法解释的特征，并为流行病学，实验室和临床调查提供机会。
Mortality rates from multiple sclerosis show a well-known north-south gradient, both within the United States and internationally. Mortality rates from prostate cancer show a similar gradient and are significantly correlated with multiple sclerosis (MS) mortality and MS prevalence. This finding adds prostate cancer to the set of diseases whose geographic distributions are significantly correlated with MS and whose members include colon cancer, dental caries, and Parkinson''s disease. Review of the literature indicates that these clinically dissimilar diseases may share an aberration in vitamin (hormone) D. Recent evidence demonstrating a multi-faceted role for vitamin D in immunoregulation suggests that a vitamin D aberration may also contribute to the etiology of MS. A vitamin D hypothesis can illuminate several unexplained features of the epidemiology of MS and suggests opportunities for epidemiologic, laboratory, and clinical investigation.