Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase
Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase
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DOI：
10.1152/ajpregu.00355.2002
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发表时间：
2003-03-01
影响因子：
2.8
通讯作者：
Van Cauter, E
中科院分区：
文献类型：
--
作者：
Buxton, OM;Lee, CW;Van Cauter, E
为了研究实际持续时间（1小时）的高强度运动对人体昼夜节律相位的直接相移效应，五组20-30岁的健康男性参加了不运动或暴露于上午，下午，晚上或夜间运动的研究。除了在预定的睡眠/黑暗和运动期间，受试者保持在允许睡眠期的改良恒定常规条件下，包括恒定姿势、时钟时间知识和暴露于平均（+/-SD）42 +/- 19 lx的昏暗光强度。血浆褪黑激素分泌的夜间开始被用作昼夜节律相的标志。使用相位响应曲线来总结运动的相移效应与运动时间的函数关系。昼夜节律时相变化受时间影响显著（P < 0.004）。在从运动前褪黑激素发作到运动后首次发作的时间间隔内，与不运动组中观察到的相位延迟（-25 +/-14 min，P < 0.05）相比，晚间运动组的昼夜节律相位显著提前30 +/-15 min（SE）。在运动暴露后的第二天，响应于晚间运动暴露的相移减弱，并且与在不运动的情况下观察到的相移不再有显著差异。在夜间运动和一些夜间运动受试者中观察到褪黑素水平的意外一过性升高。结合先前在人类和昼夜啮齿动物中的研究结果，目前的结果表明：1）较长时间的运动暴露和/或重复的每日运动暴露可能是人类昼夜节律系统可靠相移所必需的，2）傍晚高强度运动可能诱导与人类昼夜节律系统的非光夹带相关的相位提前。
To examine the immediate phase-shifting effects of high-intensity exercise of a practical duration (1 h) on human circadian phase, five groups of healthy men 20-30 yr of age participated in studies involving no exercise or exposure to morning, afternoon, evening, or nocturnal exercise. Except during scheduled sleep/dark and exercise periods, subjects remained under modified constant routine conditions allowing a sleep period and including constant posture, knowledge of clock time, and exposure to dim light intensities averaging (+/-SD) 42 +/- 19 lx. The nocturnal onset of plasma melatonin secretion was used as a marker of circadian phase. A phase response curve was used to summarize the phase-shifting effects of exercise as a function of the timing of exercise. A significant effect of time of day on circadian phase shifts was observed (P < 0.004). Over the interval from the melatonin onset before exercise to the first onset after exercise, circadian phase was significantly advanced in the evening exercise group by 30 +/- 15 min (SE) compared with the phase delays observed in the no-exercise group (-25 +/- 14 min, P < 0.05). Phase shifts in response to evening exercise exposure were attenuated on the second day after exercise exposure and no longer significantly different from phase shifts observed in the absence of exercise. Unanticipated transient elevations of melatonin levels were observed in response to nocturnal exercise and in some evening exercise subjects. Taken together with the results from previous studies in humans and diurnal rodents, the current results suggest that 1) a longer duration of exercise exposure and/or repeated daily exposure to exercise may be necessary for reliable phase-shifting of the human circadian system and that 2) early evening exercise of high intensity may induce phase advances relevant for nonphotic entrainment of the human circadian system.