Antiproliferative activity of a hybrid protein between interferon-gamma and tumor necrosis factor-beta.
Antiproliferative activity of a hybrid protein between interferon-gamma and tumor necrosis factor-beta.
复制标题
干扰素-γ 和肿瘤坏死因子-β 之间的杂合蛋白的抗增殖活性。
DOI：
10.1126/science.3138754
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Taylor,MW
中科院分区：
文献类型：
--
作者：
Feng,GS;Gray,PW;Shepard,HM;Taylor,MW
A hybrid protein between interferon-γ and tumor necrosis factor-β was made by ligating the respective genes and expressing the fused genes under the control of thetrppromoter inEscherichia coli. The antiproliferative activity of the hybrid protein in vitro was greatly increased compared with either interferon-γ or tumor necrosis factor-β alone, and both antiviral activity and cytotoxic effect were retained in the hybrid protein. The hybrid protein may have potential clinical application.
