EFFECTS OF LONG DURATION ODOR EXPOSURE ON THE UNIT-ACTIVITY OF OLFACTORY-BULB CELLS IN AWAKE RABBITS
EFFECTS OF LONG DURATION ODOR EXPOSURE ON THE UNIT-ACTIVITY OF OLFACTORY-BULB CELLS IN AWAKE RABBITS
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DOI：
10.1016/0006-8993(82)90951-9
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发表时间：
1982-01-01
期刊：
影响因子：
2.9
通讯作者：
PANHUBER, H
中科院分区：
文献类型：
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作者：
CHAPUT, MA;PANHUBER, H
在清醒兔嗅球二尖瓣细胞层连续暴露1小时前、暴露1小时中、暴露1小时后记录单单位活性。使用8个神经元进行13个完整的1小时暴露，而在暴露结束前又丢失了6个神经元。在暴露的最初几分钟内，发生了与呼吸相关的放电活动同步，这与暴露前5-s的相同气味刺激相似。这种放电模式在一些暴露的整个过程中持续，但在另一些暴露的几分钟内消失。在所有情况下，对暴露气味的反应，虽然幅度减少，但在暴露终止后6分钟是明显的。这种减少在其他气味的刺激下也被观察到，这些气味在暴露之前已经引起了反应，并且总是伴随着反应幅度的逐渐恢复。讨论了二尖瓣细胞放电活动的变化与心理物理方法观察到的适应现象之间的关系。参考二尖瓣细胞选择性变性和放射自显影2-脱氧葡萄糖实验，讨论了放电活动无明显变化。
Recordings of single unit activity before, during and after a 1-h continuous exposure were made from the mitral cell layer of the olfactory bulbs of awake rabbits. Thirteen complete 1-h exposures were performed using 8 neurons, while a further 6 neurons were lost before the end of the exposure. During the first few minutes of exposure, a respiration-related synchronization of firing activity occurred which was similar to that of the pre-exposure 5-s stimulations with the same odor. This discharge patterning continued for the full duration of some exposures but disappeared within a few minutes for others. In all cases, a response to the exposure odor, although reduced in amplitude, was evident 6 min after the exposure was terminated. This reduction was also observed for stimulations with other odors that had induced a response prior to exposure, and was always followed by a gradual recovery in the amplitude of the response. The relation between the changes in the firing activity of mitral cells during and after 1-h exposures and adaptation phenomena observed using psychophysical methods are discussed. The absence of gross changes in firing activity are discussed with reference to mitral cell selective degeneration and autoradiographic 2-deoxyglucose experiments.