Construction of photoresponsive supramolecular micelles based on ethyl cellulose graft copolymer
Construction of photoresponsive supramolecular micelles based on ethyl cellulose graft copolymer
复制标题
基于乙基纤维素接枝共聚物的光响应超分子胶束的构建
DOI：
10.1007/s10118-014-1450-9
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发表时间：
2014-06-01
影响因子：
4.3
通讯作者：
Yuan, Jin-ying
中科院分区：
文献类型：
--
作者：
Jian, Chun-mei;Liu, Bo-wen;Yuan, Jin-ying
本工作将乙基纤维素（EC）与β-环糊精（β-CD）基团和偶氮苯反式异构体（tAzo）基团的主客体相互作用结合起来，构建了一个紫外-可见光调控的乙基纤维素超分子体系。以可再生EC为大分子引发剂，引发E-己内酯（E-CL）聚合，将β-CD连接到PCL侧链末端，形成具有生物相容性和生物可降解性的梳形共聚物EC-g-PCL，并通过点击反应将β-CD连接到PCL侧链末端。同时，通过N，N '-二环己基碳二亚胺（DCC）偶联得到亲水性PEG-tAzo。用核磁共振（NMR）和凝胶渗透色谱（GPC）对产物的结构进行了表征。随后，通过β-CD和tAzo基团形成包合物，得到了以疏水性EC-g-PCL-beta-CD为核、亲水性PEG-tAzo为壳的EC-g-PCL-beta-CD/PEG-tAzo超分子体系。利用动态光散射（DLS）和透射电子显微镜（TEM）研究了胶束的粒径和粒径分布，利用核磁共振（NMR）和紫外-可见光谱（UV-Vis）研究了胶束的紫外-可见光响应性。
In this work, a UV-Visible light controlled supramolecular system based on ethyl cellulose (EC) was constructed, combining the host-guest interaction of beta-cyclodextrin (beta-CD) group and trans-isomer of azobenzene (tAzo) group. To link beta-CD to the hydrophobic section, renewable EC was used as macroinitiator to initiate the polymerization of E >-caprolactone (E >-CL) to form biocompatible and biodegradable comb copolymer EC-g-PCL, and beta-CD was attached to the end of PCL side chain via click reaction. Meanwhile, hydrophilic PEG-tAzo was obtained by N,N'-dicyclohexylcarbodiimide (DCC) coupling. Then, the structures of the products were characterized by nuclear magnetic resonance (NMR) and gel permeation chromatography (GPC). Subsequently, with the formation of inclusion complexes by beta-CD and tAzo groups, the obtained EC-g-PCL-beta-CD/PEG-tAzo supramolecular system self-assembled in water with hydrophobic EC-g-PCL-beta-CD as core and hydrophilic PEG-tAzo as shell. Furthermore, dynamic light scattering (DLS) and transmission electron microscopy (TEM) were utilized to investigate the particle size and size distribution, while NMR and UV-Vis spectra were applied to explore the UV-Visible light stimuli-responsiveness of the micelles.