Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model
Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model
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DOI：
10.1152/jn.00623.2002
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发表时间：
2003-09-01
影响因子：
2.5
通讯作者：
Brown, D
中科院分区：
文献类型：
--
作者：
Davison, AP;Feng, JF;Brown, D
在嗅球中，神经元活动的空间分布和时间结构似乎对处理气味信息都很重要，但目前不可能同时高分辨率地测量这两种信息，并在嗅球的所有层中进行测量。我们开发了一个生物学上逼真的哺乳动物嗅球模型，将二尖瓣细胞和颗粒细胞以及它们之间的树突突触结合在一起，这使我们能够详细观察网络行为。这些细胞模型是基于之前发表的工作。突触的属性是从文献中获得的。突触连接的模式是基于文献中有关球内神经元之间连接的统计数据的有限的实验数据。电刺激模拟实验的结果与已发表的实验数据在大部分细节上非常吻合。这让人们相信，该模型捕捉到了真实嗅球中网络交互的特征。该模型预测，树突抑制的时间过程取决于网络的连通性和突触的内在参数。在对模拟气味刺激的反应中，强烈激活的二尖瓣细胞倾向于抑制相邻细胞，二尖瓣细胞容易同步它们的放电，并且增加刺激强度会增加同步程度。初步实验表明，同步度的缓慢时间变化比平均发火率的空间分布更有助于区分非常相似的气味。
In the olfactory bulb, both the spatial distribution and the temporal structure of neuronal activity appear to be important for processing odor information, but it is currently impossible to measure both of these simultaneously with high resolution and in all layers of the bulb. We have developed a biologically realistic model of the mammalian olfactory bulb, incorporating the mitral and granule cells and the dendrodendritic synapses between them, which allows us to observe the network behavior in detail. The cell models were based on previously published work. The attributes of the synapses were obtained from the literature. The pattern of synaptic connections was based on the limited experimental data in the literature on the statistics of connections between neurons in the bulb. The results of simulation experiments with electrical stimulation agree closely in most details with published experimental data. This gives confidence that the model is capturing features of network interactions in the real olfactory bulb. The model predicts that the time course of dendrodendritic inhibition is dependent on the network connectivity as well as on the intrinsic parameters of the synapses. In response to simulated odor stimulation, strongly activated mitral cells tend to suppress neighboring cells, the mitral cells readily synchronize their firing, and increasing the stimulus intensity increases the degree of synchronization. Preliminary experiments suggest that slow temporal changes in the degree of synchronization are more useful in distinguishing between very similar odorants than is the spatial distribution of mean firing rate.