A review of modified DLC coatings for biological applications
A review of modified DLC coatings for biological applications
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DOI：
10.1016/s0925-9635(03)00081-5
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发表时间：
2003-03-01
影响因子：
4.1
通讯作者：
Hauert, R
中科院分区：
文献类型：
--
作者：
Hauert, R
类金刚石(DLC)又称无定形氢化碳(a-C：H)，是一类具有优异力学性能、摩擦学性能和生物性能的材料。通过将其他元素添加到DLC中，所有这些属性都可以在一定范围内改变。结果表明，在DLC膜中添加不同的元素可以影响不同蛋白质在表面的吸附比例。这些蛋白质随后将影响细胞附着、细胞增殖和细胞分化。某些有毒元素，如嵌入在类金刚石中的铜、银、钒，当暴露在生物介质中时会释放出来，引起毒性反应。这允许制备具有可调抗菌效果的表面。由于DLC转变为石墨(一种固体润滑剂)，并在其表面形成了一层传递层，DLC在许多技术应用中证明了其优异的摩擦学性能。然而，如果这种效应发生在人工关节上，这是值得怀疑的。在DLC涂层的髋关节上，文献中发现了相互矛盾的结果，有些表明有所改善，有些则恶化。DLC涂层具有良好的血液相容性，这表现在减少血栓的形成。当暴露在血液中时，在涂层表面观察到白蛋白/纤维蛋白原吸附的比率增加以及血小板活化减少。DLC涂层的心血管植入物，如人工心脏瓣膜和支架已经商业化。(C)2003 Elsevier Science B.V.保留所有权利。
Diamond-like carbon (DLC), also known as amorphous hydrogenated carbon (a-C:H), is a class of materials with excellent mechanical, tribological and biological properties. By the addition of other elements into the DLC all of these properties can be changed within a certain range. It will be shown that the ratios of the different proteins adsorbed on the surface can be influenced by the addition of different elements into the DLC film. These proteins will then subsequently influence cell attachment, cell proliferation and cell differentiation. Certain toxic elements such as Cu, Ag, V, embedded in the DLC will, when exposed to a biological media, be released and cause toxic reactions. This allows the preparation of surfaces with a tunable antibacterial effect. DLC has proven its outstanding tribological properties in many technical applications due to the transformation of DLC into graphite (a solid lubricant) and the build up of a transfer layer on the counterpart. However, it is questionable if this effect takes place in artificial joints. Contradicting results on DLC coated hip joints are found in the literature, some indicating an improvement and some a change for the worse. DLC coatings have an excellent haemocompatibility, which is expressed in a decreased thrombus formation. When exposed to blood, an increased ratio of albumin to fibrinogen adsorption as well as decreased platelet activation is observed on coated surfaces. DLC coated cardiovascular implants such as artificial heart valves and stents are already commercially available. (C) 2003 Elsevier Science B.V. All rights reserved.