STIMULATION OF MACROPHAGE PLASMINOGEN-ACTIVATOR ACTIVITY BY COLONY-STIMULATING FACTORS
STIMULATION OF MACROPHAGE PLASMINOGEN-ACTIVATOR ACTIVITY BY COLONY-STIMULATING FACTORS
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DOI：
10.1002/jcp.1041030309
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发表时间：
1980-01-01
影响因子：
5.6
通讯作者：
SHADDUCK, RK
中科院分区：
文献类型：
--
作者：
HAMILTON, JA;STANLEY, ER;SHADDUCK, RK
集落刺激因子(CSF)刺激单个造血祖细胞产生粒-巨噬细胞。两种不同亚类的纯化脑脊液的不同制剂可刺激常驻和淀粉诱导的小鼠腹腔巨噬细胞的纤溶酶原依赖的纤溶酶原激活物活性。淋巴细胞上清液也能刺激巨噬细胞纤溶酶原激活物(PA)的活性。由于它们含有集落刺激活性，因此这些上清液中可能有一个或多个亚类的脑脊液与这种作用有关。由于在炎症部位检测到集落刺激和巨噬细胞生长活性，这些发现可能反映了脑脊液在炎症过程中的作用。
Colony-stimulating factors (CSF) stimulate granulocyte-macrophage production from single hemopoietic progenitor cells. Various preparations of purified CSF of 2 different subclasses stimulated a plasminogen-dependent fibrinolytic (plasminogen activator) activity from resident and starch-induced mouse peritoneal macrophages. Lymphocyte supernatants also stimulate macrophage plasminogen activator (PA) activity. Since they contain colony stimulating activity, it is possible that 1 or more subclasses of CSF in these supernatants is responsible for this effect. Since colony-stimulating and macrophage growth activities were detected at inflammatory sites, these findings could reflect a role for CSF in inflammatory processes.