Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
Potential use of γ-secretase modulators in the treatment of Alzheimer disease.
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DOI：
10.1001/archneurol.2012.540
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发表时间：
2012-10
影响因子：
--
通讯作者：
Galasko, Douglas
中科院分区：
文献类型：
--
作者：
Wagner, Steven L.;Tanzi, Rudolph E.;Mobley, William C.;Galasko, Douglas
Although significant progress has occurred in the past 20 years regarding our understanding of Alzheimer disease pathogenesis, we have yet to identify disease-modifying therapeutics capable of substantially altering the clinical course of this prevalent neurodegenerative disease. In this short review, we discuss 2 approaches that are currently being tested clinically (γ-secretase inhibition and γ-secretase modulation) and emphasize the significant differences between these 2 therapeutic approaches. We also discuss certain genetic- and biomarker-based translational and clinical trial paradigms that may assist in developing a useful therapeutic agent.
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