MEMBRANES AND BIOREACTORS - A TECHNICAL CHALLENGE IN BIOTECHNOLOGY
MEMBRANES AND BIOREACTORS - A TECHNICAL CHALLENGE IN BIOTECHNOLOGY
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DOI：
10.1002/bit.260330814
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发表时间：
1989-03-01
影响因子：
3.8
通讯作者：
BELFORT, G
中科院分区：
文献类型：
--
作者：
BELFORT, G
将合成膜的特性与生物催化剂(如细胞和酶)相结合，形成了一种令人兴奋的新技术--膜生物反应器。这一联姻背后的推动力来自最近重组DMA和细胞融合技术的惊人进步，以及开发具有竞争力的生物处理方案以生产复杂和活性生物分子的需要。综述了膜生物反应器包埋整个细胞和酶的优点和局限性。比较了各种膜结构，如微胶囊、中空纤维和平板。介绍了几种不同的固定化膜生物反应器，包括单层膜生物反应器、叠层膜生物反应器和微孔膜生物反应器，用于光学活性对映体的转化。与新的和令人兴奋的技术一样，膜生物反应器在生物技术中的未来将取决于它们以具有竞争力的成本生产所需分子的能力。
Integrating the properties of synthetic membranes with biological catalysts such as cells and enzymes forms the basis of an exciting new technology called membrane bioreactors. The impetus behind this marriage comes from the recent spectacular advances in recombinant DMA and cell fusion technologies and the need to develop competitive bioprocessing schemes to produce complex and active biological molecules. The advantages and limitations of using membrane bioreactors for entrapping whole cells and enzymes are reviewed. Various membrane configurations such as microcapsules, hollow fibers, and flat sheets are compared. Several different entrapped membrane bioreactors, including single, laminated and microporous, for the conversion of optically active enantiomers are described. As with new and exciting technologies, the future of membrane bioreactors in biotechnology will depend on their ability to produce desired molecules at competitive costs.