A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones
A copper(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination approach to 2-quinolones
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DOI：
10.1016/j.tet.2019.130711
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发表时间：
2019-12-06
期刊：
影响因子：
2.1
通讯作者：
Taylor, Richard J. K.
中科院分区：
文献类型：
--
作者：
Gorman, Ryan M.;Hurst, Timothy E.;Taylor, Richard J. K.
介绍了一锅铜（II）自由基交叉脱氢偶联/亚磺酸消除法制备4-羧基喹啉-2- 1的新环化工艺。扩展到更复杂的底物也被报道为在目标合成中的应用，允许获得从水稻和HOFQ分离的天然产物。(C) 2019 Elsevier Ltd.版权所有。
A new cyclisation procedure to prepare 4-carboxy-quinolin-2-ones via a one-pot Cu(II)-mediated radical cross-dehydrogenative coupling/sulfinic acid elimination of linear anilides is described. Extensions to more complex substrates are also reported as are applications in target synthesis allowing access to natural products isolated from Oryza sativa and HOFQ. (C) 2019 Elsevier Ltd. All rights reserved.