Meningeal carcinomatosis: CSF cytology, immunocytochemistry and biochemical tumor markers
Meningeal carcinomatosis: CSF cytology, immunocytochemistry and biochemical tumor markers
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脑膜癌病：脑脊液细胞学、免疫细胞化学和生化肿瘤标志物
DOI：
10.1111/j.1600-0404.1994.tb02653.x
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发表时间：
1994
影响因子：
3.5
通讯作者：
W. Dorndorf
中科院分区：
文献类型：
--
作者：
P. Oschmann;M. Kaps;Jan Voelker;W. Dorndorf
对12例脑膜癌病患者的脑脊液细胞学、免疫细胞化学和生物化学肿瘤标志物进行了诊断意义和治疗对照的比较;对50例样本进行了研究。39份样本的细胞学检查为肿瘤阳性，45份样本的免疫细胞化学检查为肿瘤阳性。在47个样本中发现鞘内产生的肿瘤标志物。在初步检查中，只有免疫细胞化学检测正确分类所有病例。细胞学和生化肿瘤标志物检查分别有10例和11例阳性，两种方法联合应用可使敏感性提高到100%。在随访检查中，肿瘤标志物与症状相关性最好，是临床复发的早期指标。这些结果只有在几种单克隆抗体和生化肿瘤标志物检测相结合的情况下才能实现。结论：免疫细胞化学和生物化学肿瘤标志物对脑膜癌病的假阴性细胞学和可靠的治疗控制问题有重要帮助。
CSF cytology, immunocytochemistry and biochemical tumor markers were compared in 12 patients with a meningeal carcinomatosis regarding diagnostic significance and therapy control; 50 samples were investigated. Cytology was tumor‐positive in 39 samples and immunocytochemistry in 45 samples. Intrathecally produced tumor markers were found in 47 samples. On initial examination only immunocytochemical testing correctly classified all cases. Cytology and biochemical tumor markers revealed positive results in 10 respectively 11 of 12 patients, combined use of these two methods would increase the sensitivity to 100%. On follow‐up examination tumor markers correlated best with symptoms and were early indicators for clinical relapse. These results could be achieved only if several monoclonal antibodies and biochemical tumor marker tests were combined. It is concluded that immunocytochemistry and biochemical tumor markers are of major help regarding the problems of false‐negative cytology and reliable therapy control in meningeal carcinomatosis.