Pure red cell aplasia in a Holstein calf.
Pure red cell aplasia in a Holstein calf.
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荷斯坦犊牛纯红细胞再生障碍性贫血。
DOI：
10.1007/s00580-017-2586-0
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发表时间：
2018
影响因子：
--
通讯作者：
H.
中科院分区：
文献类型：
--
作者：
Maezawa;M.;Koyama;K.;Horiuchi;N.;Kobayashi;Y. and Inokuma;H.
一头3个月大的荷斯坦小牛出现嗜睡。血液学检查显示重度非再生性贫血，白色血细胞和血小板计数未减少。血清生化分析显示，高促红细胞生成素活性和高血清铁浓度。骨髓检查显示红细胞前体细胞选择性减少，髓细胞：红细胞比率增加至7：1。尸检时仅在骨髓中发现了可能导致贫血的病变。根据这些临床和病理结果，小牛被诊断为纯红细胞再生障碍性贫血（PRCA）。虽然PRCA的原因尚未确定，但这是荷斯坦小牛中首次证实的PRCA临床报告。
A 3-month-old Holstein calf presented with lethargy. Hematological examination showed severe non-regenerative anemia without reduction in white blood cell and platelet counts. Serum biochemical analysis revealed both high erythropoietin activity and high serum iron concentration. Bone marrow examination revealed selectively decreased erythroid precursors and an increased myeloid:erythroid ratio of 7:1. Lesions that could have caused anemia were found only in bone marrow by necropsy. The calf was diagnosed with pure red cell aplasia (PRCA) based on these clinical and pathological findings. Although the cause of PRCA was not identified, this is the first confirmed clinical report of PRCA in a Holstein calf.