Cationic Rhodium(I) Tetrafluoroborate Catalyzed Intramolecular Carbofluorination of Alkenes via Acyl Fluoride C‐F Bond Activation
Cationic Rhodium(I) Tetrafluoroborate Catalyzed Intramolecular Carbofluorination of Alkenes via Acyl Fluoride C‐F Bond Activation
复制标题
阳离子四氟硼酸铑(I)通过酰氟C-F键活化催化烯烃分子内碳氟化
DOI：
10.1002/anie.202303657
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Tobisu Mamoru
中科院分区：
文献类型：
--
作者：
Yoshida Tomoki;Ohta Masaya;Emmei Tomoya;Kodama Takuya;Tobisu Mamoru
在四氟硼酸铑（I）阳离子催化剂的存在下，酰氟的C−F键可以断裂并加成到链烯上。这种1，2-碳二亚胺反应为合成叔烷基氟衍生物提供了一种强有力的方法，其原子经济性为100%。机理研究表明，铑阳离子和四氟硼酸根阴离子的协同作用是这种催化裂解成功的关键，并以可控的方式形成C-F键。
The C−F bond of acyl fluorides can be cleaved and added across tethered alkenes in the presence of a cationic rhodium(I) tetrafluoroborate catalyst. This 1,2‐carbofluorination reaction offers a powerful method for the synthesis of tertiary alkyl fluoride derivatives with an atom economy of 100 %. Mechanistic studies indicate that the concerted action of a rhodium cation and a tetrafluoroborate anion is key for the success of this catalytic cleavage and formation of C−F bonds in a controlled manner.