Overview on milk protein-derived peptides
Overview on milk protein-derived peptides
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DOI：
10.1016/s0958-6946(98)00059-4
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发表时间：
1998-05-01
影响因子：
3.1
通讯作者：
Meisel, H
中科院分区：
文献类型：
--
作者：
Meisel, H
乳蛋白源性生物活性肽是一类具有多种生物活性的物质，是机体各种调节过程的潜在调节剂，许多肽具有多种生物活性。阿片肽是具有激动或拮抗活性的阿片受体配体。血管紧张素转换酶（ACE）抑制肽可以发挥抗高血压作用。免疫调节酪蛋白肽刺激人淋巴细胞增殖和巨噬细胞吞噬活性。抗菌肽杀死敏感微生物。抗血栓形成肽抑制纤维蛋白原与血小板表面上的特异性受体区域结合，并且还抑制血小板聚集。酪蛋白磷酸肽可形成可溶性有机磷酸盐，并可作为不同矿物质，特别是钙的载体。关于它们的作用模式，生物活性肽可以到达靶位点（例如，受体和酶）在肠道的腔侧或吸收后在外周器官中。乳源性肽可以在工业规模上生产，因此这些肽已经被考虑作为“功能性食品”中的膳食补充剂和药物应用。因此，这些肽被认为是用于食品和药物制剂的健康增强营养品。(C)1998爱思唯尔科技有限公司版权所有。
Milk protein-derived bioactive peptides include a variety of substances which are potential modulators of various regulatory processes in the body; many peptides reveal multifunctional bioactivities. Opioid peptides are opioid receptor ligands with agonistic or antagonistic activities. Angiotensin converting enzyme (ACE)-inhibitory peptides can exert an antihypertensive effect. Immunomodulating casein peptides stimulate proliferation of human lymphocytes and phagocytic activities of macrophages. Antimicrobial peptides kill sensitive microorganisms. Antithrombotic peptides inhibit frbrinogen binding to a specific receptor region on the platelet surface and also inhibit aggregation of platelets. Caseinophosphopeptides can form soluble organophosphate salts and may function as carriers for different minerals, especially calcium. In relation to their mode of action, bioactive peptides may reach target sites (e.g., receptors and enzymes) at the luminal side of the intestinal tract or, after absorption, in peripheral organs. Milk-derived peptides can be produced on an industrial scale and as a consequence these peptides have already been considered for application both as dietary supplements in 'functional foods' and as drugs. Hence, these peptides are claimed to be health enhancing nutraceuticals for food and pharmaceutical preparations. (C) 1998 Elsevier Science Ltd. All rights reserved.