CURE OF DUODENAL-ULCER ASSOCIATED WITH ERADICATION OF HELICOBACTER-PYLORI
CURE OF DUODENAL-ULCER ASSOCIATED WITH ERADICATION OF HELICOBACTER-PYLORI
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根除幽门螺杆菌可治愈十二指肠溃疡
DOI：
10.1016/0140-6736(90)91301-p
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发表时间：
1990-05-26
期刊：
影响因子：
168.9
通讯作者：
TYTGAT, GNJ
中科院分区：
文献类型：
--
作者：
RAUWS, EAJ;TYTGAT, GNJ
50例难治性十二指肠溃疡患者随机分为2组，分别接受胶体次枸橼酸铋（CBS）单用（26例）和阿莫西林和甲硝唑（24例）治疗4周。5例患者（均接受三联治疗）因副作用退出。在完成治疗的45名患者中，有17名幽门螺杆菌被根除，在12个月的随访期间没有溃疡复发。溃疡复发率在H阳性的患者中明显更高（17/21 [89%]）。幽门。9例H. pylori感染和在单独CBS治疗6个月内溃疡复发的患者随后给予三联治疗。9例中7例为H.幽门螺杆菌根除，并且在接下来的12个月内没有复发。2例仍为H.三联疗法后幽门阳性者溃疡复发。H.根除幽门而不改变胃酸分泌，将成为十二指肠溃疡治疗的主要手段，因为它能治愈这种疾病。
50 patients with intractable duodenal ulcer were randomly assigned to 4 weeks of treatment with colloidal bismuth subcitrate (CBS) alone (26 patients) or with amoxicillin and metronidazole (24 patients). 5 patients (all on triple therapy) withdrew because of side-effects. In 17 of the 45 patients who completed the treatment, Helicobater pylori was eradicated, and there was no ulcer relapse during the 12 months of follow-up. The ulcer relapse rate was significantly higher (17 of 21 [89%]) among patients who remained positive for H. pylori. 9 patients who remained positive for H. pylori and had ulcer relapses within 6 months of treatment with CBS alone were subsequently given triple therapy. 7 of the 9 showed H. pylori eradication and no relapses within the next 12 months. The 2 patients still H. pylori-positive after triple therapy had further ulcer relapses. H. pylori eradication, without altering acid output, will become the mainstay of duodenal ulcer treatment because it cures the disease.