A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.
A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.
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DOI：
10.1002/ajmg.1320180117
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发表时间：
1984-05
期刊：
影响因子：
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通讯作者：
B. Suarez;P. van Eerdewegh
中科院分区：
文献类型：
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作者：
B. Suarez;P. van Eerdewegh
两个广泛使用的影响同胞对评分程序（绿色和伍德罗[1977]程序，并形成所有可能的影响同胞对的方法）进行了比较，一种新的方法，其相对效率检测HLA连锁疾病易感基因的存在。它们的相对性能进行了研究，通过大量的疾病传播模型的广泛的计算机模拟。平均而言，新的程序似乎优于绿色和伍德罗的方法和“所有可能的对”的方法。
Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.