SPONTANEOUS INFLAMMATORY DISEASE IN TRANSGENIC RATS EXPRESSING HLA-B27 AND HUMAN BETA-2M - AN ANIMAL-MODEL OF HLA-B27-ASSOCIATED HUMAN DISORDERS
SPONTANEOUS INFLAMMATORY DISEASE IN TRANSGENIC RATS EXPRESSING HLA-B27 AND HUMAN BETA-2M - AN ANIMAL-MODEL OF HLA-B27-ASSOCIATED HUMAN DISORDERS
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DOI：
10.1016/0092-8674(90)90512-d
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发表时间：
1990-11-30
期刊：
影响因子：
64.5
通讯作者：
TAUROG, JD
中科院分区：
文献类型：
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作者：
HAMMER, RE;MAIKA, SD;TAUROG, JD
遗传了人类 I 类主要组织相容性等位基因 HLA-B27 的人类患称为脊柱关节病的多器官系统疾病的风险显着增加。为了研究 B27 在这些疾病中的作用，我们将 B27 和人 β2-微球蛋白基因引入大鼠体内，已知该物种对实验诱导的炎症性疾病非常敏感。来自一种转基因品系的大鼠自发出现炎症性疾病，涉及胃肠道、外周和椎关节、男性生殖道、皮肤、指甲和心脏。这种器官系统受累模式与 B27 相关的人类疾病极为相似。这些结果证实 B27 在脊柱关节病的多器官系统过程的发病机制中发挥核心作用。这种转基因模型应该有助于阐明 B27 的作用。
Humans who have inherited the human class I major histocompatibility allele HLA-B27 have a markedly increased risk of developing the multi-organ system diseases termed spondyloarthropathies. To investigate the role of B27 in these disorders, we introduced the B27 and human .beta.2-microglobulin genes into rats, a species known to be quite susceptible to experimentally induced inflammatory disease. Rats from one transgenic line spontaneously developed inflammatory disease involving the gastrointestinal tract, peripheral and vertebral joints, male genital tract, skin, nails, and heart. This pattern of organ system involvement showed a striking resemblance to the B27-associated human disorders. These results establish that B27 plasy a central role in the pathogenesis of the multi-organ system processess of the spondyloarthropathies. Elucidation of the role of B27 should be facilitated by this transgenic model.