Development of mechanical circulatory support devices at the University of Tokyo
Development of mechanical circulatory support devices at the University of Tokyo
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DOI：
10.1007/s10047-006-0368-6
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发表时间：
2007-06
影响因子：
1.3
通讯作者：
Y. Abe;T. Isoyama;I. Saito;S. Mochizuki;M. Ono;H. Nakagawa;Noriyuki Taniguchi;N. Mitsumune;Ayaka Sugino;M. Mitsui;K. Takiura;T. Ono;A. Kouno;T. Chinzei;S. Takamoto;K. Imachi
中科院分区：
文献类型：
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作者：
Y. Abe;T. Isoyama;I. Saito;S. Mochizuki;M. Ono;H. Nakagawa;Noriyuki Taniguchi;N. Mitsumune;Ayaka Sugino;M. Mitsui;K. Takiura;T. Ono;A. Kouno;T. Chinzei;S. Takamoto;K. Imachi
东京大学机械循环支持装置的开发重点是开发小型全人工心脏 (TAH)，因为使用体外气动驱动 TAH 的动物实现了 532 天的存活。波动泵就是为了满足这个目的而发明的。波动泵全人工心脏（UPTAH）是一种使用波动泵的植入式 TAH。迄今为止，UPTAH 已被植入 71 只体重从 39 公斤至 72 公斤的山羊身上。控制方法在动物实验中非常重要，吸吮控制就是为了防止心房吸吮而发展起来的。通过监测左心房压力进行快速左右平衡控制，以防止与动物变得烦躁相关的动脉压和静脉回流快速增加引起的急性肺水肿。此外，应用 1/R 控制来稳定右心房压力。通过应用这些控制方法，7只山羊存活了1个多月。最长存活期为63天。我们期望用最新的 TAH 模型进行长期动物实验。除了 TAH 之外，自 2002 年以来，基于 UPTAH 的技术，还开发了波动泵心室辅助装置 (UPVAD)，即植入式心室辅助装置 (VAD)。 UPVAD 被植入六只山羊体内；三只山羊存活了1个多月。虽然需要进一步的研究和开发来完成 UPVAD 系统，但 UPVAD 具有作为植入式脉动流 VAD 实现的良好潜力。
The development of mechanical circulatory support devices at the University of Tokyo has focused on developing a small total artificial heart (TAH) since achieving 532 days of survival of an animal with a paracorporial pneumatically driven TAH. The undulation pump was invented to meet this purpose. The undulation pump total artificial heart (UPTAH) is an implantable TAH that uses an undulation pump. To date, the UPTAH has been implanted in 71 goats weighting from 39 to 72 kg. The control methods are very important in animal experiments, and sucking control was developed to prevent atrial sucking. Rapid left–right balance control was performed by monitoring left atrial pressure to prevent acute lung edema caused by the rapid increase in both arterial pressure and venous return associated with the animal becoming agitated. Additionally, 1/R control was applied to stabilize the right atrial pressure. By applying these control methods, seven goats survived more than 1 month. The maximum survival period was 63 days. We are expecting to carry out longer term animal experiments with a recent model of TAH. In addition to the TAH, an undulation pump ventricular assist device (UPVAD), which is an implantable ventricular assist device (VAD), has been in development since 2002, based on the technology of the UPTAH. The UPVAD was implanted in six goats; three goats survived for more than 1 month. While further research and development is required to complete the the UPVAD system, the UPVAD has good potential to be realized as an implantable pulsatile-flow VAD.