A new insight into male genome reprogramming by histone variants and histone code
A new insight into male genome reprogramming by histone variants and histone code
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DOI：
10.4161/cc.7.22.6975
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发表时间：
2008-11-15
期刊：
影响因子：
4.3
通讯作者：
Khochbin, Saadi
中科院分区：
文献类型：
--
作者：
Boussouar, Faycal;Rousseaux, Sophie;Khochbin, Saadi
包装的雄性基因组本质上含有非组蛋白，这表明在体细胞中定义的大多数表观遗传标记在成熟雄配子中无效，并且新的特定规则在雄性生殖细胞中的表观遗传信息传递中占主导地位。最近的研究发现了一种男性特异性基因组重编程机制，该机制可能与 DNA 甲基化合作并延伸到 DNA 甲基化之外，指定基因组的不同区域，并且可以编码传输到卵子的新型表观遗传信息。在这里，我们强调了这种非常规男性特异性表观遗传密码的一般特征，它很大程度上依赖于组蛋白变体和特定组蛋白修饰的使用。
The very nature of the packed male genome, essentially containing non-histone proteins, suggests that most of the epigenetic marks which have been defined in somatic cells are not valid in mature male gametes and that new specific rules prevail for the transmission of epigenetic information in male germ cells. Recent investigations are now uncovering a male-specific genome reprogramming mechanism, which likely cooperates with and extends beyond DNA methylation, specifying different regions of the genome and which could encode a new type of epigenetic information transmitted to the egg. Here we highlight the general traits of this unconventional male-specific epigenetic code, which largely relies on the use of histone variants and specific histone modifications.