The role of rat dorsomedial prefrontal cortex in working memory for egocentric responses.
The role of rat dorsomedial prefrontal cortex in working memory for egocentric responses.
复制标题
大鼠背内侧前额叶皮层在工作记忆中自我中心反应的作用。
DOI：
10.1016/s0304-3940(01)02020-1
复制
发表时间：
2001
影响因子：
2.5
通讯作者：
Kesner,RP
中科院分区：
文献类型：
--
作者：
Ragozzino,ME;Kesner,RP
本实验研究了内侧中央前区和前扣带回的喹啉酸（90 mM）损伤对自我中心反应的工作记忆的影响。老鼠接受了延迟匹配样本任务的训练，其中涉及 90° 右转或左转的记忆。结果表明，与术前水平相比，病变大鼠在 10 秒延迟条件下的评分显着下降。与对照组相比，延迟时间增加到 20 秒会显着降低受损大鼠的工作记忆性能。这些发现表明，大鼠内侧中央前区和/或前扣带回区在自我中心反应的工作记忆中发挥重要作用。
The present experiment studied the effects of quinolinic acid (90 mM) lesions of the medial precentral and anterior cingulate on working memory for egocentric responses. Rats were trained on a delayed match-to-sample task that involved memory for a 90° right or left turn. The results indicated that lesioned rats had significantly decreased scores during the 10 s delay condition compared to presurgery levels. An increase in the delay to 20 s significantly reduced working memory performance in the lesioned rats compared to that of controls. These findings suggest that the rat medial precentral and/or anterior cingulate area play an important role in working memory for egocentric responses.