Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4
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DOI：
10.1016/s0092-8674(00)80799-0
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发表时间：
1999-06-25
期刊：
影响因子：
64.5
通讯作者：
Hafen, E
中科院分区：
文献类型：
--
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
生长的调控对于后生动物的发育至关重要。在此，我们表明CHICO（脊椎动物IRS1 - 4的果蝇同源物）在细胞大小和生长的调控中起着关键作用。chico突变的动物体型不到野生型果蝇的一半，这是因为其细胞数量更少且更小。在嵌合体动物中，chico纯合细胞比其杂合的同胞细胞生长更慢，细胞大小自主减小，并且形成的器官也较小。尽管chico果蝇体型较小，但它们的脂质水平却几乎增加了P倍。由chico和果蝇胰岛素受体基因突变以及脊椎动物中胰岛素/IGF1信号通路的扰动所导致的生长缺陷的相似性表明，该通路通过控制细胞大小、细胞数量和代谢，在整体生长的调节中发挥着保守的作用。
The control of growth is fundamental to the developing metazoan. Here, we show that CHICO, a Drosophila homolog of vertebrate IRS1-4, plays an essential role in the control of cell size and growth. Animals mutant for chico are less than half the size of wild-type flies, owing to fewer and smaller cells. In mosaic animals, chico homozygous cells grow slower than their heterozygous siblings, show an autonomous reduction in cell size, and form organs of reduced size. Although chico flies are smaller, they show an almost P-fold increase in lipid levels. The similarities of the growth defects caused by mutations in chico and the insulin receptor gene in Drosophila and by perturbations of the insulin/IGF1 signaling pathway in vertebrates suggest that this pathway plays a conserved role in the regulation of overall growth by controling cell size, cell number, and metabolism.