Extended-spectrum β-lactamases, carbapenemases and the mcr-1 gene: is there a historical link?
Extended-spectrum β-lactamases, carbapenemases and the mcr-1 gene: is there a historical link?
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DOI：
10.1016/j.ijantimicag.2016.11.026
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发表时间：
2017-03-01
影响因子：
10.8
通讯作者：
Letellier, Ann
中科院分区：
文献类型：
--
作者：
Rhouma, Mohamed;Letellier, Ann
最近在五大洲发现了编码肠杆菌科粘菌素抗性的质粒介导的 mcr-1 基因。本研究的目的是追踪有关 mcr-1 基因以及 ESBL 和碳青霉烯酶基因的发现和出现的历史事件，因为一些研究报告在产生超广谱 β-内酰胺酶 (ESBL) 和/或碳青霉烯酶的大肠杆菌中鉴定出 mcr-1 基因。一项回顾性研究报道了 20 世纪 80 年代分离的大肠杆菌菌株中 mcr-1 基因的鉴定，这似乎与 ESBL 酶的首次鉴定相对应。 2009 年首次发现新德里金属-β-内酰胺酶-1 (NDM-1)，该酶与从食用动物获得的大肠杆菌菌株中 mcr-1 基因流行率显着增加有关。我们注意到，自 20 世纪 80 年代以来，mcr-1、ESBL 和碳青霉烯酶基因之间就存在历史联系，我们认为，重新评估粘菌素在牲畜中的使用需要采取总体方法，不仅包括减少粘菌素的使用，还包括减少所有抗生素的使用。 (C) 2017 年 Elsevier B.V. 和国际化疗协会。版权所有。
The plasmid mediated mcr-1 gene encoding for Enterobacteriaceae colistin resistance has been recently identified across five continents. The objective of the present study was to trace historical events concerning the discovery and emergence of the mcr-1 gene along with ESBL and carbapenemase genes since several studies have reported identifying mcr-1 genes among Extended-Spectrum beta-Lactamases (ESBL) and/or carbapenemase producing Escherichia coli. A retrospective study reported the identification of the mcr-1 gene in E. coli strains isolated in the 1980s, and this seems to correspond to the first identification of ESBL enzymes. The first discovery of the New Delhi metallo-beta-lactamase-1 (NDM-1) in 2009 was associated with a significant increase in mcr-1 gene prevalence in E. coli strains obtained from food producing animals. We noticed that a historical link has existed between mcr-1, ESBL and carbapenemase genes since the 1980s, and we believe that the re-evaluation of colistin use in livestock needs an overall approach that includes not only colistin use reduction but also the reduction of all antibiotic use. (C) 2017 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.