RALGA (Diacnéal®) Decreases Melanin Content in a Human Skin Model
RALGA (Diacnéal®) Decreases Melanin Content in a Human Skin Model
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RALGA (Diacnéal®) 降低人体皮肤模型中的黑色素含量
DOI：
10.1159/000081503
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发表时间：
2005
期刊：
影响因子：
3.4
通讯作者：
F. Verrière
中科院分区：
文献类型：
--
作者：
S. Boisnic;M. Branchet;T. Nocera;F. Verrière
背景：视黄醛和乙醇酸 RALGA (Diacnéal®) 均可有效局部治疗痤疮。使用 Diacnéal 3 个月后，观察到炎症后色素沉着有所减少。目的：使用幸存的人类皮肤的原始模型来验证这种关联对色素沉着的影响。方法：人皮肤外植体在器官培养中保持存活 14 天。 Diacnéal® 每天都使用。皮肤色素沉着取决于黑素体从黑素细胞到角质形成细胞的转移，通过丰塔纳-马森染色在组织学上可视化。 DOPA反应后测定黑素细胞的数量。结果：使用 Diacnéal 后黑色素含量有所减少。黑素细胞的数量没有改变。结论：这些结果表明 RALGA (Diacnéal®) 可能有助于预防痤疮炎症后色素沉着。
Background: Retinaldehyde and glycolic acid RALGA (Diacnéal®) are both effective in the topical treatment of acne. A decrease in the postinflammatory pigmentation has been observed after application of Diacnéal during 3 months. Aim: To verify the effect of this association on pigmentation using an original model of surviving human skin. Methods: Human skin explants were maintained alive in organ culture for 14 days. Diacnéal® was applied every day. Pigmentation of skin, depending on the transfer of melanosomes from melanocytes to keratinocytes, was visualized histologically by Fontana-Masson staining. The number of melanocytes was determined after the DOPA reaction. Results: A decrease in melanin content was shown after application of Diacnéal. The number of melanocytes was not modified. Conclusion: These results suggest that RALGA (Diacnéal®) may be of interest to prevent the postinflammatory pigmentation of acne.