The barrier function of skin: how to keep a tight lid on water loss.
The barrier function of skin: how to keep a tight lid on water loss.
复制标题
皮肤的屏障功能：如何防止水分流失。
DOI：
10.1016/s0962-8924(02)02316-4
复制
发表时间：
2002
影响因子：
19
通讯作者：
Jones,JonathanCR
中科院分区：
文献类型：
--
作者：
Tsuruta,Daisuke;Green,KathleenJ;Getsios,Spiro;Jones,JonathanCR
如果没有表皮，我们的处境就会很糟糕。表皮层不仅保护我们免受环境病原体的侵害，而且还充当水分流失的“屏障”。多年来，皮肤研究人员一直致力于对屏障分子性质的识别，该领域的共识是，位于表皮上层的蛋白质-脂质层对于建立和维持水屏障是必要的。现在，有证据表明，细胞间连接的组成部分（称为紧密连接）在皮肤屏障功能的发展中也发挥着重要作用。值得注意的是，这些数据支持了 30 多年前提出的假设。
Without an epidermis, we would be in a sorry state. The epidermal layer not only protects us from environmental pathogens but also acts as a ‘barrier' to water loss. The identification of the molecular nature of the barrier has occupied the efforts of skin researchers over many years, with the consensus in the field being that a protein–lipid layer, located in the upper layers of the epidermis, is necessary for establishment and maintenance of a water barrier. Now, evidence has been presented that components of intercellular junctions, termed tight junctions, also play an essential role in development of barrier function in the skin. Remarkably, the data support a hypothesis that was presented more than 30 years ago.