Endemic and epidemic lineages of Escherichia coli that cause urinary tract infections
Endemic and epidemic lineages of Escherichia coli that cause urinary tract infections
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DOI：
10.3201/eid1410.080102
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发表时间：
2008-10-01
影响因子：
11.8
通讯作者：
Tellier, Pierre-Paul
中科院分区：
文献类型：
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作者：
Manges, Amee R.;Tabor, Helen;Tellier, Pierre-Paul
美国加州（1999-2001年）尿路感染（UTIs）妇女感染了密切相关或无法区分的大肠杆菌菌株（克隆群），这表明点源传播。我们比较了引起UTI的E.在加州的大肠杆菌与在加拿大的蒙特利尔、魁北克引起这种感染的菌株。2006年在蒙特利尔社区获得性尿路感染妇女的尿液标本进行了大肠杆菌培养。杆菌引起256次连续UTI发作的分离株的特征在于抗菌药物敏感性谱、肠细菌重复基因间共有序列2 PCR、血清分型、Xbal和Notl脉冲场凝胶电泳、多位点序列分型和系统发育分型。我们证实了耐药的、遗传相关的和时间上聚集的大肠杆菌的存在。大肠杆菌克隆群，导致社区获得性尿路感染无关的妇女在2个地点和2个不同的时间。在两个地点都鉴定出两个克隆群。流行性传播后，地方性传播的UTI引起的克隆群体可以解释这些集群的UTI病例。
Women with urinary tract infections (UTIs) in California, USA (1999-2001), were infected with closely related or indistinguishable strains of Escherichia coli (clonal groups), which suggests point source dissemination. We compared strains of UTI-causing E. coli in California with strains causing such infections in Montreal, Quebec, Canada. Urine specimens from women with community-acquired UTIs in Montreal (2006) were cultured for E. coli. Isolates that caused 256 consecutive episodes of UTI were characterized by antimicrobial drug susceptibility profile, enterobacterial repetitive intergenic consensus 2 PCR, serotyping, Xbal and Notl pulsed-field gel electrophoresis, multilocus sequence typing, and phylogenetic typing. We confirmed the presence of drug-resistant, genetically related, and temporally clustered E. coli clonal groups that caused community-acquired UTIs in unrelated women in 2 locations and 2 different times. Two clonal groups were identified in both locations. Epidemic transmission followed by endemic transmission of UTI-causing clonal groups may explain these clusters of UTI cases.