Rapid recurrence and malignant transformation of a benign meningioma after pregnancy: a case report
Rapid recurrence and malignant transformation of a benign meningioma after pregnancy: a case report
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DOI：
10.1080/02688697.2020.1817323
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发表时间：
2020-09-11
影响因子：
1.1
通讯作者：
Wang, Lei
中科院分区：
文献类型：
--
作者：
He, Lei;Yu, Shuqing;Wang, Lei
我们报告一位年轻女性在怀孕期间发生良性脑膜瘤的快速复发及恶变。一位30岁女性于怀孕前接受良性脑膜瘤手术（WHO I级）。在怀孕前两个月的核磁共振检查中没有发现复发的迹象。随后的MRI在她分娩后6个月进行。MRI结果显示复发性脑膜瘤，大小为45 x 49 x 32 mm。随后进行了再次手术，组织病理学检查显示非典型脑膜炎脑膜瘤（WHO II级），Ki-67水平约为10%，PR表达高于70%;未观察到ER。据我们所知，这是第一次报告的快速恶性转化的良性脑膜瘤在怀孕期间。
We report rapid recurrence and malignant transformation of a benign meningioma during pregnancy in a young woman. A 30-year-old female meeted an operation of benign meningioma (WHO Grade I) before her pregnancy. No signs of recurrence were found in MRI two months before her pregnancy. Subsequent MRI was performed 6 months after her giving birth. MRI results showed a recurrent meningioma with a size of 45 x 49 x 32 mm. Reoperation was performed later, histopathological workup showed an atypical meningothelial meningioma(WHO Grade II) with a Ki-67 level of about 10% and a PR expression above 70%; no ER was observed. To our best knowledge, this is the first report of the rapid malignant transformation of a benign meningioma during pregnancy.