Peroxiredoxins and Redox Signaling in Plants.
Peroxiredoxins and Redox Signaling in Plants.
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DOI：
10.1089/ars.2017.7164
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发表时间：
2018-03-01
影响因子：
6.6
通讯作者：
Dietz KJ
中科院分区：
文献类型：
--
作者：
Liebthal M;Maynard D;Dietz KJ
意义：过氧化物氧化酶（Prxs）是一种硫醇过氧化物酶，在细胞的抗氧化防御和氧化还原信号网络中具有多种功能。我们不断进步的认识赋予植物Prx的局部和全球意义，它们分为四种Prx类型。在植物中，它们定位于细胞质、线粒体、质体和细胞核。抗氧化防御从根本上与氧化还原信号、细胞通讯和驯化有关。巯基二硫网络是应力感知和处理响应的核心部分，并将信息输入与氧化还原调节集成在一起。最新进展：Prxs在网络中作为氧化还原感觉系统和氧化还原依赖的相互作用体发挥作用。Prxs直接或间接靶向的过程包括基因表达、转录后反应（包括翻译、翻译后调控、代谢途径的切换或调节）以及其他细胞活动。最先进的知识可用于叶绿体2-CysPrx，其中最近已定义了一个固体相互作用组。蛋白质结构和共表达的计算机分析强化了对2-CysPrx功能的新见解。关键问题：到目前为止，Prxs经常被研究酶活性的局部性质。对突变体的体外和离体研究将揭示Prxs干扰多种细胞成分的能力，包括与Ca2+连接的信号通路、激素信号和蛋白质稳态的串扰。未来方向：Prxs敲除系与模拟特定状态的变体互补，即缺乏过氧化物酶活性，缺乏寡聚化能力，类似于高氧化十聚体，或具有截断的c端，应该允许剖析作为硫醇过氧化物酶，氧化剂，相互作用伙伴和伴侣的作用。Antioxid。氧化还原信号，28,609-624。
Significance: Peroxiredoxins (Prxs) are thiol peroxidases with multiple functions in the antioxidant defense and redox signaling network of the cell. Our progressing understanding assigns both local and global significance to plant Prxs, which are grouped in four Prx types. In plants they are localized to the cytosol, mitochondrion, plastid, and nucleus. Antioxidant defense is fundamentally connected to redox signaling, cellular communication, and acclimation. The thiol–disulfide network is central part of the stress sensing and processing response and integrates information input with redox regulation. Recent Advances: Prxs function both as redox sensory system within the network and redox-dependent interactors. The processes directly or indirectly targeted by Prxs include gene expression, post-transcriptional reactions, including translation, post-translational regulation, and switching or tuning of metabolic pathways, and other cell activities. The most advanced knowledge is available for the chloroplast 2-CysPrx wherein recently a solid interactome has been defined. An in silico analysis of protein structure and coexpression reinforces new insights into the 2-CysPrx functionality. Critical Issues: Up to now, Prxs often have been investigated for local properties of enzyme activity. In vitro and ex vivo work with mutants will reveal the ability of Prxs to interfere with multiple cellular components, including crosstalk with Ca2+-linked signaling pathways, hormone signaling, and protein homeostasis. Future Directions: Complementation of the Prxs knockout lines with variants that mimic specific states, namely devoid of peroxidase activity, lacking the oligomerization ability, resembling the hyperoxidized decamer, or with truncated C-terminus, should allow dissecting the roles as thiol peroxidase, oxidant, interaction partner, and chaperone. Antioxid. Redox Signal. 28, 609–624.
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影响因子：
4.8
作者：
Collin, V;Issakidis-Bourguet, E;Miginiac-Maslow, M
通讯作者：
Miginiac-Maslow, M
影响因子：
7.3
作者：
Cerveau, Delphine;Ouahrani, Djelloul;Rey, Pascal
通讯作者：
Rey, Pascal
影响因子：
4.1
作者：
Bedhomme, Mariette;Adamo, Mattia;Trost, Paolo
通讯作者：
Trost, Paolo
影响因子：
2.9
作者：
Cha, MK;Yun, CH;Kim, IH
通讯作者：
Kim, IH
DOI：
10.1186/1939-8433-5-17
发表时间：
2012-07-19
期刊：
Rice (New York, N.Y.)
影响因子：
--
作者：
Cao P;Jung KH;Choi D;Hwang D;Zhu J;Ronald PC
通讯作者：
Ronald PC