Mitochondrial dysfunction in a rat model and the related risk of metabolic disorders.
Mitochondrial dysfunction in a rat model and the related risk of metabolic disorders.
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DOI：
10.19852/j.cnki.jtcm.20221017.001
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发表时间：
2023
影响因子：
2.6
通讯作者：
Chen Hui
中科院分区：
文献类型：
--
作者：
L I Han;Huang Xiaomin;Cai Haiyang;Herok George;H E Jing;S U Yixun;L I Weihong;Y I Chenju;Oliver Brian G;Chen Hui
To explore whether kidney deficiency (KYD) is prone to metabolic disorders may be linked to impaired mitochondrial function in thermogenesis and metabolic tissues.A rat model of KYD was used, which was established using Sprague Dawley rat dams with warm preference subjected to herbal treatment that can improve kidney . The human relevance was confirmed by reduced serum corticosterone levels, and increased preference for warm location.KYD Rats were underdeveloped. Adenosine-triphosphate (ATP) production was reduced in the brown fat, but increased in the muscle. However, oxidative phosphorylated complexes to generate ATP and mitochondrial biogenesis marker were reduced in both tissues. When the second insult of high-fat diet (HFD) was introduced, KYD rats gained less weight yet developed more severe lipid and glucose metabolic disorders. This may be driven by disregulated liver gluconeogenesis marker forkhead box protein O1 and lipid metabolic regulator cholesterol 7 alpha-hydroxylase.KYD rats exhibited reduced mito-chondrial function in the brown fat, but were partially compensated by skeletal muscle, associated with the phenotype of warm preference and metabolic disorder, which was further exacerbated by additional HFD consumption. Future studies can focus on treatment targetting mitochondria function to reverse this phenotype.
