The role of Notch signalling in ovarian angiogenesis.
The role of Notch signalling in ovarian angiogenesis.
复制标题
Notch信号在卵巢血管生成中的作用
DOI：
10.1186/s13048-017-0308-5
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发表时间：
2017-03-11
影响因子：
4
通讯作者：
Liu J
中科院分区：
文献类型：
--
作者：
Xie Q;Cheng Z;Chen X;Lobe CG;Liu J
在成人，卵巢的特点是广泛的血管生成和有规律的快速生长间隔。卵巢的功能依赖于血管新生血管网络，这些血管网络使卵泡和/或黄体获得氧气、营养物质和激素支持。血管生成异常参与了多囊卵巢综合征、卵巢癌等病理性卵巢的发生发展。Notch信号通路是血管生成的主要调节因子之一，也是卵巢疾病的治疗靶点。在此，我们将对Notch信号通路在卵巢中的表达模式以及Notch信号通路在卵巢血管生成中的作用进行综述。
In adults, the ovary is characterized with extensive angiogenesis and regular intervals of rapid growth. Ovarian function is dependent on the network of angiogenic vessels which enable the follicle and/or corpus luteum to receive oxygen, nutrients and hormonal support. Abnormal angiogenesis is involved in the induction and development of pathological ovary, such as polycystic ovary syndrome and ovarian cancer. Notch signalling pathway is one of the primary regulators of angiogenesis and a therapeutic target for ovarian diseases. Here, we will review literatures on the expression pattern of Notch pathway components in the ovary and on the role of Notch signalling pathway on ovarian angiogenesis.