Lower placental telomere length may be attributed to maternal residential traffic exposure; a twin study
Lower placental telomere length may be attributed to maternal residential traffic exposure; a twin study
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DOI：
10.1016/j.envint.2015.02.008
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发表时间：
2015-06-01
影响因子：
11.8
通讯作者：
Nawrot, Tim S.
中科院分区：
文献类型：
--
作者：
Bijnens, Esmee;Zeegers, Maurice P.;Nawrot, Tim S.
背景：个体之间端粒长度的高度差异在出生前就已经存在，并且在新生儿和成人中一样广泛。环境暴露可能对这一观察结果有影响，但在很大程度上仍未确定。我们假设双胞胎胎盘端粒长度与住宅交通暴露有关，这是自由基的重要环境来源，可能会加速衰老。接下来，我们打算通过估计胎盘端粒长度的遗传力来揭示自然-培育对胎盘端粒长度的贡献。方法：在东弗兰德斯前瞻性双胞胎调查中，我们测量了211对双胞胎胎盘组织的端粒长度。使用地理信息系统确定产妇交通暴露。此外，我们估计了变异的遗传和环境来源的相对重要性。结果：在本双胞胎研究中，胎盘组织端粒长度的变化主要由共同环境决定。产妇居住地靠近主要道路与胎盘端粒长度有关：到最近的主要道路的距离增加一倍与出生时胎盘端粒长度增加5.32% （95% CI: 1.90至8.86%;p = 0.003）有关。此外，母亲居住环境绿化（5公里缓冲）的四分位数增加（22%）与胎盘端粒长度增加3.62% （95% CI: 0.20至7.15%;p = 0.04）相关。结论：总之，我们发现母亲居住距离交通较近，居住环境绿化程度较低与出生时胎盘端粒长度较短有关。这或许可以解释，由于端粒缩短加速了许多疾病的发展，与空气污染有关的不良健康后果在很大程度上始于生命早期。(C) 2015 Elsevier Ltd.版权所有。
Background: High variation in telomere length between individuals is already present before birth and is as wide among newborns as in adults. Environmental exposures likely have an impact on this observation, but remain largely unidentified. We hypothesize that placental telomere length in twins is associated with residential traffic exposure, an important environmental source of free radicals that might accelerate aging. Next, we intend to unravel the nature-nurture contribution to placental telomere length by estimating the heritability of placental telomere length.Methods: We measured the telomere length in placental tissues of 211 twins in the East Flanders Prospective Twin Survey. Maternal traffic exposure was determined using a geographic information system. Additionally, we estimated the relative importance of genetic and environmental sources of variance.Results: In this twin study, a variation in telomere length in the placental tissue was mainly determined by the common environment. Maternal residential proximity to a major road was associated with placental telomere length: a doubling in the distance to the nearest major road was associated with a 5.32% (95% CI: 1.90 to 8.86%; p = 0.003) longer placental telomere length at birth. In addition, an interquartile increase (22%) in maternal residential surrounding greenness (5 km buffer) was associated with an increase of 3.62% (95% CI: 0.20 to 7.15%; p = 0.04) in placental telomere length.Conclusions: In conclusion, we showed that maternal residential proximity to traffic and lower residential surrounding greenness is associated with shorter placental telomere length at birth. This may explain a significant proportion of air pollution-related adverse health outcomes starting from early life, since shortened telomeres accelerate the progression of many diseases. (C) 2015 Elsevier Ltd. All rights reserved.