DIPETALONEMA-WITEI, FILARIAL PARASITE OF THE JIRD, MERIONES-LIBYCUS .1. MAINTENANCE IN THE LABORATORY
DIPETALONEMA-WITEI, FILARIAL PARASITE OF THE JIRD, MERIONES-LIBYCUS .1. MAINTENANCE IN THE LABORATORY
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DOI：
10.2307/3275034
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发表时间：
1961-01-01
影响因子：
1.3
通讯作者：
TERRY, A
中科院分区：
文献类型：
--
作者：
WORMS, MJ;TERRY, RJ;TERRY, A
本文详细介绍了该丝虫的实验室维护及其由自然媒介塔塔科夫斯基鸟蛛传播的情况。微丝蚴在29[degree]C下20-25天内发育到感染阶段;这些第三阶段的幼虫将在蜱中存活并具有感染性长达203天。也成功地传播了与Ornithodorus moubata。仓鼠是D. witei。微丝蚴在脊椎动物宿主组织中的分布一般与其他丝虫中发现的分布一致，只是在骨骼肌中的浓度高于通常。对几种已知的杀丝虫药物进行了针对感染的测试;只有含有锑或砷的药物有效;乙胺嗪对蠕虫和微丝蚴都没有活性。将该感染与卡氏溪螨在棉鼠中的感染作为实验室感染进行比较。结论是D. witei更容易维持在小规模，但对于筛选潜在的杀丝虫剂可能不太有用。
The laboratory maintenance of this filaria and its transmission by the natural vector Ornithodorus tartakovskyi is described in detail. The microfilariae develop to the infective stage at 29[degree]C in 20-25 days; these third stage larvae will remain alive and infective in the tick up to 203 days. Successful transmission has also been achieved with Ornithodorus moubata. The hamster has been shown to be a satisfactory primary host for D. witei. The distribution of the microfilariae in the tissues of the vertebrate host conforms generally to that found in other filariae except for a higher concentration than usual in the skeletal muscle. Several known filaricidal drugs were tested against the infection; only those containing antimony or arsenic were effective; diethylcarbamazine was inactive against both adult worms and microfilariae. The infection is compared with that of Litomosoides carinii in the cotton rat as a laboratory infection. It is concluded that D. witei is easier to maintain on a small scale but is probably less useful for screening potential filaricides.