Social rhythm regularity and the onset of affective episodes in bipolar spectrum individuals.
Social rhythm regularity and the onset of affective episodes in bipolar spectrum individuals.
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DOI：
10.1111/j.1399-5618.2008.00583.x
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发表时间：
2008-06
影响因子：
5.4
通讯作者：
Gail H C Shen;L. Alloy;L. Abramson;L. Sylvia
中科院分区：
文献类型：
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作者：
Gail H C Shen;L. Alloy;L. Abramson;L. Sylvia
研究表明，双相情感障碍患者的社会节奏规律性可能低于正常对照组，这可能有助于他们的情感症状和发作。本研究探讨是否规律性前瞻性地预测时间发作的重性抑郁症，轻躁狂和躁狂发作的样本与双相谱系障碍。方法：我们从天普大学和威斯康星州大学招募了414名被诊断为循环性心境障碍、双相II型障碍或无情感障碍的本科生（正常对照）。参与者在时间1完成了社会节奏指标，大约每四个月进行一次结构化访谈，平均随访期为33个月。结果被诊断患有循环心境障碍和双相II型障碍的参与者报告的常规活动明显少于正常对照组，并且其中大约一半的参与者在研究期间经历了病情恶化。生存分析表明，诊断和社会节奏的规律性显着预测的时间参与者的第一次预期发作的重性抑郁症，轻躁狂和躁狂发作。结论双相情感障碍患者的社会节律规律性低于正常对照组，这与社会时代性理论相一致，可预测患者的情感发作生存时间。
OBJECTIVES Research suggests that bipolar disorder individuals may have less social rhythm regularity than normal controls and that this may contribute to their affective symptoms and episodes. This study examined whether regularity prospectively predicted time to onset of major depressive, hypomanic and manic episodes in a sample with bipolar spectrum disorders. METHODS We recruited 414 undergraduate students from Temple University and University of Wisconsin diagnosed with cyclothymia, bipolar II disorder, or with no affective disorder (normal controls). Participants completed the Social Rhythm Metric at Time 1 and structured interviews approximately every four months for an average follow-up period of 33 months. RESULTS Participants diagnosed with cyclothymia and bipolar II disorder reported significantly fewer regular activities than normal controls, and approximately half of these participants experienced a worsening course of their illness over the study duration. Survival analyses indicated that both diagnosis and social rhythm regularity significantly predicted the time to participants' first prospective onset of major depressive, hypomanic and manic episodes. CONCLUSION Consistent with the social zeitgeber theory, bipolar spectrum participants reported less social rhythm regularity than normal controls, which prospectively predicted the survival time to affective episodes.