How effective are cardiopulmonary bypass circuits at removing gaseous microemboli?
How effective are cardiopulmonary bypass circuits at removing gaseous microemboli?
复制标题
心肺旁路回路在清除气体微栓塞方面的效果如何？
DOI：
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
D. Stump
中科院分区：
文献类型：
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作者：
T. Jones;D. Deal;J. C. Vernon;Noel Blackburn;D. Stump
体外循环（CPB）期间血管内微栓塞与器官损伤之间存在关联。在CPB过程中，空气可能被无意中引入静脉，导致气态微栓子（GME）的形成。我们研究了来自五个不同制造商的CPB电路去除因空气进入静脉而产生的GME的能力。采用成人CPB体外模型，将60ml空气引入静脉，在5个位置监测GME通过回路元件的进展。在所有回路中，在将空气引入静脉后，在动脉线检测到GME。在电路去除GME的能力方面，各制造商之间存在很大差异。在CPB过程中，空气进入静脉导致GME的形成，GME能够通过包括动脉过滤器在内的所有电路元件。在动脉线路中检测到的GME的数量受电路元件设计的影响，并且因制造商而异。应避免空气进入静脉，如果有空气必须立即处理。
An association has been demonstrated between intravascular microemboli and organ injury during cardiopulmonary bypass (CPB). Air may be inadvertently introduced into the venous line during CPB resulting in the formation of gaseous microemboli (GME). We studied the ability of CPB circuits, from five different manufacturers, to remove GME originating from the introduction of air into the venous line. Using an in vitro model of adult CPB, 60 ml of air was introduced into the venous line and the progression of GME through the circuit components was monitored at 5 locations. In all circuits GME were detected in the arterial line following the introduction of air into the venous line. There was a wide variation between manufacturers in the ability of the circuit to remove GME. Air introduced into the venous line during CPB results in the formation of GME that are able to pass through all the circuit components including the arterial filter. The quantity of GME detected in the arterial line is influenced by the design of the circuit components and varies between manufacturers. Air in the venous line should be avoided and if present it must be dealt with promptly.
用细胞保护剂处理清除的血液可减少脑脂质微栓塞。
DOI：
10.1016/s0003-4975(00)01588-5
发表时间：
2000
期刊：
The Annals of thoracic surgery
影响因子：
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作者：
Kincaid,EH;Jones,TJ;Stump,DA;Brown,WR;Moody,DM;Deal,DD;HammonJr,JW
通讯作者：
HammonJr,JW