Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.
Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway.
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DOI：
10.2174/1874091x01408010074
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Matsuda S
中科院分区：
文献类型：
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作者：
Kitagishi Y;Nakanishi A;Minami A;Asai Y;Yasui M;Iwaizako A;Suzuki M;Ono Y;Ogura Y;Matsuda S
PI 3 K/AKT信号通路在胰岛β细胞保护中发挥重要作用，通过刺激细胞增殖和抑制细胞凋亡来提高胰岛β细胞存活率。因此，这一途径似乎在2型糖尿病中至关重要。了解这一途径的调控可能会为新的治疗方法提供更好的疗效。本文就PI 3 K/AKT通路参与胰岛β细胞胞内信号转导的研究进展作一综述。近年来的研究表明，营养可能通过激活PI 3 K/AKT通路来调节胰岛β细胞的存活，因此，我们也对2型糖尿病的饮食特点、相关生活方式及其信号通路的研究进行了综述。导致该疾病的分子机制是大量研究的主题，因为对发病机制的更好理解将导致针对疾病状况的新疗法。
PI3K/AKT pathway has been shown to play a pivotal role on islet β-cell protection, enhancing β-cell survival by stimulating cell proliferation and inhibiting cell apoptosis. Accordingly, this pathway appears to be crucial in type-2 diabetes. Understanding the regulations of this pathway may provide a better efficacy of new therapeutic approaches. In this review, we summarize advances on the involvement of the PI3K/AKT pathway in hypothetical intra-cellular signaling of islet β-cells. As recent findings may show the nutritional regulation of the survival pathway in the islet β-cells through activation of the PI3K/AKT pathway, we also review studies on the features of several diets, correlated lifestyle, and its signaling pathway involved in type-2 diabetes. The molecular mechanisms contributing to the disease are the subject of considerable investigation, as a better understanding of the pathogenesis will lead to novel therapies against a condition of the disease.