A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats.
A progressive glomerulosclerosis occurring in partial five-sixths nephrectomized rats.
复制标题
进行性肾小球硬化发生在部分六分之五肾切除的大鼠中。
DOI：
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发表时间：
1975
影响因子：
6
通讯作者：
A. Morrison
中科院分区：
文献类型：
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作者：
T. Shimamura;A. Morrison
用Wistar白化病雄性幼鼠行5/6肾切除术，诱发慢性肾病。肾切除术后10 ~ 50周，在不同的时间间隔处死各组大鼠（每组3只），用光镜和电镜观察肾小球结构。光镜下可见肾小球体积增大，内脏系膜肾小球上皮细胞肥大，早在第10周时就已明显。肾小球玻璃样变在第25周开始明显，并在第50周时逐渐变得更广泛。电镜下见肥大的肾小球上皮细胞胞浆内有大量嗜锇小体和空泡，足突融合。从第30周开始，系膜基质明显增加，增加明显的区域内皮细胞和上皮细胞消失。增加的基质逐渐侵入并阻塞毛细血管腔和Bowman氏腔，导致陈旧性肾小球形成。这些肾小球改变是否是由于5/6肾切除术后发生的肾小球超滤引起的尚待阐明。
A chronic renal disease was induced by 5/6 nephrectomy in young adult Wistar albino male rats. Groups of 3 rats were killed at varying time intervals from 10 to 50 weeks after nephrectomy, and the glomerular structure was studied by light and electron microscopy. By light microscopy, increase in glomerular size and hypertrophy of the visceral glomerular epithelial cells were evident as early as the tenth week. Significant degree of glomerular hyalinization started on the 25th week and gradually became more extensive in involvement towards the 50th week. By electron miscroscopy, the hypertrophied glomerular epithelia showed many osmiophilic bodies and vacuoles in their cytoplasm and fusion of foot processes. Beginning on the 30th week, increase of the mesangial matrix was quite evident, and endothelial and epithelial cells disappeared from the areas where the increase was prominent. The increased matrix gradually encroached and occluded capillary lumina and Bowman's space, leading to a formation of obsolescent glomeruli. Whether or not these glomerular changes are due to the glomerular hyperfiltration which has been known to occur after 5/6 nephrectomy remains to be elucidated.