Prior exercise does not alter the incretin response to a subsequent meal in obese women.
Prior exercise does not alter the incretin response to a subsequent meal in obese women.
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DOI：
10.1016/j.peptides.2015.07.004
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发表时间：
2015-09
期刊：
影响因子：
3
通讯作者：
Kanaley JA
中科院分区：
文献类型：
--
作者：
Nyhoff LM;Heden TD;Leidy HJ;Winn NC;Park YM;Thyfault JP;Kanaley JA
先前的研究表明，GLP-1浓度在运动过程中增加，但这次运动是在餐后进行的。本研究的目的是检查肠促胰岛素对肥胖受试者在不同强度的运动后进餐的反应。11名女性（BMI>37.3±7.0 kg/m2;年龄24.3±4.6岁）参加了3个平衡研究日，在标准餐之前：1）无运动（NoEx），2）ModEx（55% VO 2 max）和3）IntEx（4 min（80% VO 2 max）/3 min（50% VO 2 max）。在整个280分钟的测试中，频繁分析血液样本的葡萄糖、乳酸盐、胰岛素、胰高血糖素、胰高血糖素样肽-1（GLP-1）、葡萄糖依赖性促胰岛素多肽（GIP）和C肽浓度。在运动或进餐期间，葡萄糖浓度在不同条件下没有差异。运动和恢复期间的胰岛素水平在条件之间没有差异，但ModEx与NoEx中的餐后胰岛素增量曲线下面积较低（p<0.01）。运动期间，不同条件下的GIP和GLP-1水平没有差异，但在运动恢复期间，ModEx中的GLP-1浓度高于NoEx（p=0.03）。膳食增加了肠促胰岛素反应（P<0.01），但这种反应不受先前运动的影响。胰高血糖素浓度随着运动而增加（P<0.05），并且在恢复期间继续升高，与NoEx相比，IntEx的增加最大（P<0.05）。在肝胰岛素提取、胰岛素分泌或胰岛素敏感性方面，未检测到条件之间的差异。晚餐前的运动对下一餐的肠促胰岛素反应没有影响，但在运动后的用餐期间胰岛素浓度较低。运动强度对这种反应没有影响。
Prior research has shown an increase in GLP-1 concentrations during exercise but this exercise bout was conducted postprandially. The purpose of this study was to examine the incretin response to a meal following an exercise bout of different intensities in obese subjects. Eleven women (BMI>37.3±7.0 kg/m2; Age 24.3±4.6 y) participated in 3 counter-balanced study days where a standardized meal was preceded by: 1) No exercise (NoEx), 2) ModEx (55% VO2max), and 3) IntEx(4 min (80% VO2max)/3 min (50% VO2max). Frequent blood samples were analyzed for glucose, lactate, insulin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and C-peptide concentrations throughout 280 min of testing. Glucose concentrations were not different between conditions during exercise or meals. There were no differences between conditions in insulin levels during exercise and recovery, but postprandial insulin incremental area under the curve was lower in ModEx vs. NoEx (p<0.01). GIP and GLP-1 levels were not different between conditions during exercise, but during exercise recovery, GLP-1 concentrations were higher in ModEx vs. NoEx (p=0.03). The meal increased the incretin responses (P<0.01) but this response was not affected by prior exercise. Glucagon concentrations increased with exercise (P<0.05) and continued to be elevated during recovery, with the greatest increase with IntEx compared with NoEx (P<0.05). No differences between conditions were detected for hepatic insulin extraction, insulin secretion, or insulin sensitivity. Exercise prior to an evening meal has no impact on the incretin response to the subsequent meal, yet insulin concentrations were lower during the meals that followed exercise. Exercise intensity had no impact on this response.