Total synthesis of the tylophora alkaloids rusplinone, 13aα-secoantofine, and antofine using a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction
Total synthesis of the tylophora alkaloids rusplinone, 13aα-secoantofine, and antofine using a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction
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DOI：
10.1016/j.tet.2010.03.021
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发表时间：
2010-06-26
期刊：
影响因子：
2.1
通讯作者：
Lambert, Tristan H.
中科院分区：
文献类型：
--
作者：
Ambrosini, Lisa M.;Cernak, Tim A.;Lambert, Tristan H.
提出了一种快速合成 tylophora 生物碱 antofine 和 13a α-secoantofine 的方法，该方法利用多催化氧化氨基氯羰基化/Friedel-Crafts 反应作为关键步骤。该反应与一锅三步伸缩工艺一起提供了三锅或四锅序列，以高总产率获得标题化合物。 (C) 2010 Elsevier Ltd. 保留所有权利。
A rapid synthetic approach to the tylophora alkaloids antofine and 13a alpha-secoantofine is presented that makes use of a multicatalytic oxidative aminochlorocarbonylation/Friedel-Crafts reaction as the key step. This reaction, along with a one-pot, three-step telescoped process offers a three or four-pot sequence to access the title compounds in high overall yield. (C) 2010 Elsevier Ltd. All rights reserved.