Animal Model Development for the Penn State Pediatric Ventricular Assist Device
Animal Model Development for the Penn State Pediatric Ventricular Assist Device
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DOI：
10.1111/j.1525-1594.2009.00896.x
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发表时间：
2009-11-01
影响因子：
2.4
通讯作者：
Weiss, William J.
中科院分区：
文献类型：
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作者：
Carney, Elizabeth L.;Clark, J. Brian;Weiss, William J.
2004年3月，国家心脏、肺和血液研究所授予五份合同，开发为患有先天性和获得性心脏病的婴儿和儿童提供循环支持的设备。自2004年以来，宾夕法尼亚州立医学院的团队已经开发出一种带有机械倾斜盘状阀的气动心室辅助装置(VAD)。到目前为止，已经对16只动物的血流动力学性能、血栓形成和溶血进行了长期评估，其中包括4只侏儒山羊和12只绵羊。主要并发症，主要是呼吸衰竭，已经由一个多学科团队遇到并解决。多种模式的止痛、适当的抗生素治疗和细心的动物护理有助于成功的结果。植入后时间从0天到40天不等。最近，一只植入了版本3婴儿VAD的绵羊在移植后35天被选择性终止，没有发生重大不良事件。这份报告描述了一个成功的评估儿童VAD的体内模型。
In March 2004, the National Heart, Lung, and Blood Institute awarded five contracts to develop devices providing circulatory support for infants and small children with congenital and acquired cardiac disease. Since 2004, the team at Penn State College of Medicine has developed a pneumatically actuated ventricular assist device (VAD) with mechanical tilting disk valves. To date, hemodynamic performance, thrombogenesis, and hemolysis have been chronically evaluated in 16 animals, including 4 pygmy goats and 12 sheep. Major complications, mainly respiratory failure, have been encountered and resolved by a multi-disciplinary team. Multi-modal analgesia, appropriate antibiotic therapy, and attentive animal care have contributed to successful outcomes. Time after implant has ranged from 0 to 40 days. Most recently, a sheep implanted with Version 3 Infant VAD was electively terminated at 35 days postimplant, with no major adverse events. This report describes a successful in vivo model for evaluating a pediatric VAD.