Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses.
Theoretical Implications of a Pre-Erythrocytic Plasmodium vivax Vaccine for Preventing Relapses.
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DOI：
10.1016/j.pt.2016.12.011
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发表时间：
2017-04
影响因子：
9.6
通讯作者：
Mueller I
中科院分区：
文献类型：
--
作者：
White M;Amino R;Mueller I
通过接种疫苗预防疟疾感染需要防止蚊子叮咬接种的每一个子孢子：这是恶性疟原虫面临的主要挑战。间日疟原虫子孢子由引起原发感染的快速子孢子和引起复发的缓慢子孢子组成。我们假设，一种对原发感染效力较低的候选间日疟原虫疫苗可能通过预防复发而大大减少传播。
Preventing malaria infection through vaccination requires preventing every sporozoite inoculated by mosquito bite: a major challenge for Plasmodium falciparum. Plasmodium vivax sporozoites consist of tachysporozoites causing primary infection and bradysporozoites leading to relapses. We hypothesise that a candidate P. vivax vaccine with low efficacy against primary infection may substantially reduce transmission by preventing relapses.