Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia
Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia
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DOI：
10.1016/j.bbr.2006.09.008
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发表时间：
2006-12-15
影响因子：
2.7
通讯作者：
Prolic, Zlatko
中科院分区：
文献类型：
--
作者：
Janac, Branka;Radenovic, Lidija;Prolic, Zlatko
除了形态学变化外，全脑缺血还可导致功能变化，这些变化可通过行为检查进行评估。本研究的目的是探讨全脑缺血时间对蒙古沙土鼠运动行为的影响。沙土鼠颈总动脉闭塞5 min、10 min、15 min，再灌注后24 h、48 h、4 d、7 d、14 d、21 d、28 d在旷场记录运动行为。每个会议持续了60分钟，由6个10分钟的间隔。我们的研究结果表明，缺血沙鼠迅速发展运动和刻板的多动，与预期的休息时间减少。在沙土鼠中观察到最明显的效果，其运动活性在7天后恢复到接近正常值。相反，全脑缺血的持续时间对直立、顺时针或逆时针旋转没有影响。这些发现表明，暴露于全球性脑缺血诱导运动，刻板，和休息时间的变化。这些影响的程度和持续时间取决于缺血的持续时间。(c)2006 Elsevier B.V.保留所有权利。
In addition to morphological changes, global cerebral ischemia leads to functional changes that can be assessed by behavioral examination. The purpose of this study was to investigate the impact of the duration of global cerebral ischemia on the time course of a comprehensive set of motor behaviors in Mongolian gerbils. The common carotid arteries of gerbils were occluded either for 5 min, 10 min, or 15 min. Gerbil motor behavior was recorded in the open field at 24 h, 48 h, 4 days, 7 days, 14 days, 21 days, and 28 days after reperfusion. Each session lasted for 60 min and was composed of six intervals of 10 min. Our results revealed that ischemic gerbils quickly develop locomotor and stereotypic hyperactivity, with the expected decrease of resting time. The most evident effect was observed in gerbils submitted to a 15 min ischemia, whose locomotor activity returned to nearly normal values after 7 days. In contrast, the duration of global cerebral ischemia had no effects on rearing, clockwise, or counter-clockwise rotation. These findings indicate that exposure to global cerebral ischernia induces changes in locomotion, stereotypy, and resting time. The magnitude and duration of these effects depend on the duration of ischernia. (c) 2006 Elsevier B.V. All rights reserved.