Involvement of protein kinase C in the galanin-induced antinociception in the brain of rats
Involvement of protein kinase C in the galanin-induced antinociception in the brain of rats
复制标题
DOI：
10.1016/j.neulet.2011.04.029
复制
发表时间：
2011-06-15
影响因子：
2.5
通讯作者：
Yu, Long-Chuan
中科院分区：
文献类型：
--
作者：
Jiao, Shi;Fu, Li-Bo;Yu, Long-Chuan
本实验室先前的研究表明，下丘脑弓状核内微量注射甘丙肽可产生抗伤害性感受作用。在本研究中，我们研究了蛋白激酶C（PKC）和PKC信号通路参与甘丙肽诱导的大鼠脑抗伤害感受。侧脑室注射甘丙肽对大鼠的热板和RandallSelitto实验均有镇痛作用。有趣的是，甘丙肽诱导的抗伤害性反应被脑室注射PKC抑制剂白屈菜红碱显著减弱，表明PKC参与甘丙肽诱导的大鼠抗伤害性反应。综上所述，结果表明甘丙肽在大鼠大脑中诱导抗伤害性感受作用，而PKC参与了甘丙肽诱导的大鼠大脑抗伤害性感受作用。(C)2011爱思唯尔爱尔兰有限公司保留所有权利。
Previous study in our laboratory demonstrates that microinjection of galanin into the arcuate nucleus of hypothalamus produced antinociceptive effects in rats. In the present study we investigated the involvement of protein kinase C (PKC) and PKC signaling pathways in the galanin-induced antinociception in the brain of rats. Intracerebroventricular injection of galanin produced antinociceptive effects in rats tested by hot-plate and Randall Selitto test. Interestingly, the galanin-induced antinociception was significantly attenuated by intracerebroventricular injection of the PKC inhibitor chelerythrine, indicating an involvement of PKC in the galanin-induced antinociception in rats. Taken together, the results demonstrate that galanin induces antinociceptive effects in the rat brain, and PKC is involved in the galanin-induced antinociception in the brain of rats. (C) 2011 Elsevier Ireland Ltd. All rights reserved.