Pulse pressure/stroke index and left ventricular geometry and function:: the LIFE Study
Pulse pressure/stroke index and left ventricular geometry and function:: the LIFE Study
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DOI：
10.1097/00004872-200304000-00022
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发表时间：
2003-04-01
影响因子：
4.9
通讯作者：
Devereux, RB
中科院分区：
文献类型：
--
作者：
Palmieri, V;Bella, JN;Devereux, RB
目的探讨以脉压/心搏指数比值（PP/SVi）估测的动脉僵硬度与左室几何形态和功能异常的关系。参与本研究的患者患有II-III期高血压和心电图左心室肥厚;排除了有冠心病或节段性室壁运动异常病史的患者。血浆葡萄糖，总和高密度脂蛋白（HDL）胆固醇和肌酐浓度和尿白蛋白/肌酐进行了评估通过标准methods.Results的研究样本（n=667）被细分为三分之一的PP/SVi。随着PP/SVi、年龄、女性比例和2型糖尿病患病率的增加，收缩压和平均血压升高，而体重指数、身高和舒张压降低。总胆固醇和高密度脂蛋白胆固醇、肌酐和白蛋白尿在三组之间没有差异。校正年龄、性别和体型后，PP/SVi与左心室几何形状同心相关，但与左心室质量和主动脉根部直径呈弱负相关;主动脉纤维钙化和左心房直径的患病率在PP/SVi的三分位数之间没有差异。PP/SVi与更大的左心室收缩末期应力相关; PP/SVi越大，应力校正的左心室功能越大，而心肌收缩力在三组之间没有显著差异。更大的PP/SVI与更大的二尖瓣E波/A波比值和更短的等容舒张时间独立的年龄，性别，左心室几何形状，收缩功能和其他confronter.Conclusion增加估计动脉僵硬度与同心左心室几何形状和舒张期左心室异常提示舒张期左心室僵硬度增加。
Objective To evaluate the relationship between arterial stiffness estimated by the pulse pressure/stroke index ratio (PP/SVi) and prognostically relevant abnormalities of left ventricular geometry and function.Methods Baseline data from the echocardiographic substudy of the Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study were used. Patients involved in the present study had stage II-III hypertension and electrocardiographic left ventricular hypertrophy; those with a history of coronary heart disease or segmental wall motion abnormalities were excluded. Plasma glucose, total and high-density lipoprotein (HDL) cholesterol and creatinine concentrations and urinary albumin/creatinine were assessed by standard methods.Results The study sample (n=667) was subdivided into tertiles of PP/SVi. With greater PP/SVi, age, proportion of women and prevalence of type 2 diabetes, systolic and mean blood pressures were greater, whereas body mass index, body height and diastolic blood pressure were lower. Total and HDL cholesterol, creatinine and albuminuria did not differ among the three groups. After adjustment for age, sex and body size, greater PP/SVi was related to concentric left ventricular geometry, but showed a weak negative relationship to left ventricular mass and aortic root diameter; the prevalence of aortic fibrocalcification and left atrial diameter did not differ among tertiles of PP/SVi. PP/SVi was related to greater left ventricular end-systolic stress; stress-corrected left ventricular chamber function was greater with greater PP/SVi, whereas myocardial contractility did not differ significantly among the three groups. Greater PP/SVI was related to greater mitral E-wave/A-wave ratio and shorter isovolumic relaxation time independently of age, sex, left ventricular geometry, systolic function and other confounders.Conclusion Increased estimated arterial stiffness is associated with concentric left ventricular geometry and with diastolic left ventricular abnormalities suggestive of increased diastolic left ventricular stiffness.